Description
Dermenkephalin is an exogenous opioid peptide that acts as an agonist at δ-opioid receptors (selective for δ-2 receptors). Dermenkephalin, like other δOR agonists, exhibits antinociceptive/analgesic activity, increasing response latency in animal models of thermal pain. Dermenkephalin also plays a role in reward and reinforcement signaling, inducing conditioned place preference in animal models previously administered ethanol or cocaine. Dermenkephalin also increases locomotor activity in animal models.