LKT Labs

Biochemicals for Life Science Research

Diclofenac Related Compound A

Diclofenac Related Compound A

Product ID D324094
Cas No. 15362-40-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $68.30 In stock
100 mg $102.90 In stock
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Description

Diclofenac Related Compound A is an impurity of diclofenac.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat inflammation associated with arthritis and gout as well as other pain or inflammatory disorders; it is somewhat selective in inhibiting COX-2 over COX-1. Diclofenac exhibits anti-inflammatory, antipyretic, analgesic, antinociceptive, anticonvulsant, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In vitro, the anticonvulsant/antiepileptic activity of diclofenac may stem from inhibition of delayed rectifier K+ channel amplitude and acceleration of channel inactivation; it also increases the amplitude of M-type K+ channels. This compound inhibits DMH-induced colon carcinogenesis in vivo, decreasing levels of COX-2, VEGF, and MCP-1. Diclofenac also decreases the epithelial-to-mesenchymal transition (EMT), suppressing squamous cell carcinoma tumor growth.

Product Info

Cas No.

15362-40-0
Purity

≥98%
Formula

C14H9Cl2NO
Formula Wt.

278.13
Chemical Name

1-(2,6-dichlorophenyl)-2-indolinone
IUPAC Name

1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one
Synonym

Diclofenac impurity 4, Diclofenac impurity I, Diclofenac lactam, 1-(2,6-Dichlorophenyl)indolin-2-one, Diclofenac Amide, 1-(2,6-dichlorophenyl)-3H-indol-2-one, 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

D324094 MSDS PDF
Info Sheet

D324094 Info Sheet PDF

References

Ziylan, A., Dogan, S., Agopcan, S. et al. Sonochemical degradation of diclofenac: byproduct assessment, reaction mechanisms and environmental considerations. Environ Sci Pollut Res 21, 5929–5939 (2014). https://doi.org/10.1007/s11356-014-2514-7

Stephan Schmidt, Sven Hanelt, Carsten Canitz,et al. Synthetic Strategies for the Modification of Diclofenac Synlett 2017; 28(15): 1984-1989 DOI: 10.1055/s-0036-1588858

Arumugam A, Weng Z, Talwelkar SS, et al. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PLoS One. 2013 Nov 8;8(11):e80076. PMID: 24260338.

Akbari E, Mirzaei E, Shahabi Majd N. Long-term Morphine-treated Rats are more Sensitive to Antinociceptive Effect of Diclofenac than the Morphine-naive rats. Iran J Pharm Res. 2013 Winter;12(1):175-84. PMID: 24250586.

Huang CW, Hung TY, Liao YK, et al. Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study. J Physiol Pharmacol. 2013 Jun;64(3):269-80. PMID: 23959723.

Kaur J, Sanyal SN. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. Mol Carcinog. 2011 Sep;50(9):707-18. PMID: 21268133.

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