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Didymin is a flavonoid glycoside found in citrus fruits that displays antioxidative and anticancer chemotherapeutic activities. In cellular and animal models of non-small cell lung cancer (NSCLC), didymin induces Fas-mediated apoptosis and delays tumor growth. Additionally, didymin downregulates PI3K, pAkt, Akt, and vimentin expression and decreases levels of CDK4, n-Myc, and cyclins B1 and D1 in vitro. In animal models of neuroblastoma, didymin decreases tumor size.
| Cas No. | 14259-47-3 |
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| Purity | ≥98% |
| Formula | C28H34O14 |
| Formula Wt. | 594.56 |
| Chemical Name | Isosakuranetin-7-O-rutinoside |
| IUPAC Name | 5-hydroxy-2-(4-methoxyphenyl)-7-[3,4,5-trihydroxy-6-[(3,4, 5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-2, 3-dihydrochromen-4-one |
| Synonym | (S)-5,7-Dihydroxy-4′-methoxyflavanone-7-β-rutinoside Isosakuranetin |
| Solubility | MeOH |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Singhal J, Nagaprashantha LD, Vatsyayan R, et al. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer Prev Res (Phila). 2012 Mar;5(3):473-83. PMID: 22174364.
Hung JY, Hsu YL, Ko YC, et al. Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo. Lung Cancer. 2010 Jun;68(3):366-74. PMID: 19733932.