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Dihydrocytochalasin B is a mycotoxin derivative that inhibits actin polymerization, preventing mitosis. Dihydrocytochalasin B exhibits anti-parasitic activity, inhibiting the growth of Entamoeba invadens. Additionally, dihydrocytochalasin B exhibits neuromodulatory activity, enhancing the conversion of Kv1.1 K+ channels to A-type K+ channels.
| Cas No. | 39156-67-7 |
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| Purity | ≥98% |
| Formula | C29H39NO5 |
| Formula Wt. | 481.62 |
| IUPAC Name | (1S,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione |
| Melting Point | 203-205°C |
| Solubility | Acetone, DMSO, 100% Ethanol, Methanol |
| Appearance | White Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Makioka A, Kumagai M, Kobayashi S, et al. Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens. Parasitol Res. 2004 May;93(1):68-71. PMID: 15103555.
Reshetnikova G, Barkan R, Popov B, et al. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein. Exp Cell Res. 2000 Aug 25;259(1):35-53. PMID: 10942577.
Jing J, Chikvashvili D, Singer-Lahat D, et al. Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvbeta1.1 subunits modulated by G protein beta gamma subunits. EMBO J. 1999 Mar 1;18(5):1245-56. PMID: 10064591.