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Dihydrokainic acid is an inhibitor of GLT-1, preventing cellular uptake of glutamate. Dihydrokainic acid exhibits neuromodulatory activity and may induce excitotoxicity and excessive NMDA receptor activation. In vivo, dihydrokainic acid attenuates binge drinking behavior.
| Cas No. | 52497-36-6 |
|---|---|
| Purity | ≥98% |
| Formula | C10H17NO4 |
| Formula Wt. | 215.25 |
| IUPAC Name | 3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid |
| Synonym | 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid |
| Melting Point | 285°C(dec.) |
| Solubility | Soluble in water (>110mg/mL). |
| Appearance | White Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Smith KL, John CS, Sypek EI, et al. Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice. Alcohol Clin Exp Res. 2014 May;38(5):1307-14. PMID: 24655029.
Nie H, Weng HR. Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats. J Neurophysiol. 2010 May;103(5):2570-80. PMID: 20220084.