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Dobutamine is a β1-adrenergic agonist that also displays weak agonist activity at β2- and α1-adrenergic receptors. Dobutamine is a positive inotrope, stimulating sympathetic nervous system activity to increase cardiac output. Dobutamine is clinically used to treat heart failure and cardiogenic shock and is used in research models to induce cardiac dysfunction. Dobutamine also decreases GABAergic, glycinergic, and glutamatergic neurotransmission to cardiac vagal neurons.
| Cas No. | 49745-95-1 |
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| Purity | ≥98% |
| Formula | C18H23NO3 HCl |
| Formula Wt. | 337.85 |
| Chemical Name | 4-[2-[[3-(4-Hydroxyphenyl)1-methylpropyl]amino]- ethyl]-1,2-benzenediol hydrochloride |
| IUPAC Name | 4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1, 2-diol;hydrochloride |
| Synonym | Dobutrex  |
| Melting Point | 184-186°C |
| Solubility | Soluble in water, alcohol and pyridine. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Bateman RJ, Boychuk CR, Philbin KE, et al. β adrenergic receptor modulation of neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuroscience. 2012 May 17;210:58-66. PMID: 22425752.
Coons JC, McGraw M, Murali S. Pharmacotherapy for acute heart failure syndromes. Am J Health Syst Pharm. 2011 Jan 1;68(1):21-35. PMID: 21164062.
Previtali M, Camporotondo R, Repetto A, et al. Dobutamine stress echocardiography for assessing the role of dynamic intraventricular obstruction in left ventricular ballooning syndrome. Cardiovasc Ultrasound. 2010 Apr 9;8:11. PMID: 20380731.