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Doripenem Hydrate

Doripenem Hydrate

Product ID D5869
Cas No. 364622-82-2
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $101.00 In stock
25 mg $202.20 In stock
100 mg $561.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Doripenem is a β-lactam carbapenem antibiotic that displays antibacterial activity against both gram-negative and gram-positive bacteria, especially Pseudomonas and Enterobacteriaceae. Doripenem binds penicillin-binding proteins 2 and 3 (PBP2/3), inhibiting cell wall peptidoglycan formation.

Product Info

Cas No.

364622-82-2

Purity

≥99%

Formula

C15H24N4O6S2 • H2O

Formula Wt.

438.52

Chemical Name

(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S, 5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2. 0]hept-2-ene-2-carboxylic acid;hydrate

IUPAC Name

(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S, 5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2. 0]hept-2-ene-2-carboxylic acid;hydrate

Appearance

White to yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D5869 MSDS PDF

Info Sheet

D5869 Info Sheet PDF

References

Schneider KD, Ortega CJ, Renck NA, et al. Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem. J Mol Biol. 2011 Mar 4;406(4):583-94. PMID: 21215758.

Davies TA, Shang W, Bush K, et al. Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008 Apr;52(4):1510-2. PMID: 18250190.

Jones RN, Huynh HK, Biedenbach DJ, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. PMID: 15190031.

Custom Order

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