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Doxifluridine

Doxifluridine

Product ID D5692
Cas No. 3094-09-5
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $75.10 In stock
100 mg $135.10 In stock
250 mg $338.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Doxifluridine is a pyrimidine nucleoside analog that exhibits anticancer chemotherapeutic activity. Doxifluridine is a prodrug of 5-fluorouracil that is activated by thymidine phosphorylase. In vivo, doxifluridine inhibits thymidylate synthase and clinically, it is used to treat various forms of cancer. This compound induces apoptosis in gastric carcinoma models and downregulates expression of FasL and PD-ECGF.

Product Info

Cas No.

3094-09-5

Purity

≥98%

Formula

C9H11FN2O5

Formula Wt.

246.19

Chemical Name

5'-Deoxy-5-fluorouridine

IUPAC Name

1-[(2R,3R,4S,5R)-3, 4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione

Synonym

5'-DFUR, Flutron, Furtulon

Melting Point

189-190°C

Solubility

Soluble in water (50 mg/mL), DMSO (10 mg/mL).

Appearance

White Needle Crystal

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D5692 MSDS PDF

Info Sheet

D5692 Info Sheet PDF

References

Zhao WH, Wang SF, Ding W, et al. Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action. World J Gastroenterol. 2006 Mar 7;12(9):1356-61. PMID: 16552801.

Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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