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Doxifluridine is a pyrimidine nucleoside analog that exhibits anticancer chemotherapeutic activity. Doxifluridine is a prodrug of 5-fluorouracil that is activated by thymidine phosphorylase. In vivo, doxifluridine inhibits thymidylate synthase and clinically, it is used to treat various forms of cancer. This compound induces apoptosis in gastric carcinoma models and downregulates expression of FasL and PD-ECGF.
| Cas No. | 3094-09-5 |
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| Purity | ≥98% |
| Formula | C9H11FN2O5 |
| Formula Wt. | 246.19 |
| Chemical Name | 5'-Deoxy-5-fluorouridine |
| IUPAC Name | 1-[(2R,3R,4S,5R)-3, 4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione |
| Synonym | 5'-DFUR, Flutron, Furtulon |
| Melting Point | 189-190°C |
| Solubility | Soluble in water (50 mg/mL), DMSO (10 mg/mL). |
| Appearance | White Needle Crystal |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhao WH, Wang SF, Ding W, et al. Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action. World J Gastroenterol. 2006 Mar 7;12(9):1356-61. PMID: 16552801.
Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.