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DT-2216

DT-2216

Product ID D760022
Cas No. 2365172-42-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $198.50 In stock
5 mg $396.90 In stock
10 mg $600.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

DT-2216 is a proteolysis targeting chimera degrader which specifically targets Bcl-xL.

Product Info

Cas No.

2365172-42-3

Purity

≥98%

Formula

C77H96ClF3N10O10S4

Formula Wt.

1542.36

IUPAC Name

(2S,4R)-1-[(2S)-2-[[7-[4-[(3R)-3-[4-[[4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]benzoyl]sulfamoyl]-2-(trifluoromethylsulfonyl)anilino]-4-phenylsulfanylbutyl]piperazin-1-yl]-7-oxoheptanoyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

Synonym

DT2216

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

D760022 Info Sheet PDF

References

Negi A, Voisin-Chiret A. Strategies to reduce the on-target platelet toxicity of Bcl-xl inhibitors: PROTACs, SNIPERs, and prodrug-based approaches. Chembiochem. 2022 Jun 20;23(12):e202100689. PMID: 35263486

Shebl B, Ng D, Lalazar G, et al. Targeting BCL-XL in fibromellar hepatocellular carcinoma. JCI Insight. 2022 Sep 8;7(17):e161820. PMID: 36073545

Khan S, Wiegand J, Zhang P, et al. BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers. J Hematol Oncol. 2022 Mar 9;15(1):23. PMID: 35260176

Thummuri D, Khan S, Underwood P, et al. Overcoming gemcitabine resistance in pancreatic cancer using the BCL-XL-specific degrader DT2216. Mol Cancer Ther. 2022 Jan;21(1):184-192. PMID: 34667112

Custom Order

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