LKT Labs

Biochemicals for Life Science Research

Echinacoside

Echinacoside

Product ID E0929
Cas No. 82854-37-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.00 In stock
10 mg $159.00 In stock
25 mg $296.00 In stock
Bulk Quote

Quicklinks

Description

Echinacoside is a phenylethanoid glycoside found in Echinacea, among other sources; it exhibits neuroprotective and vasodilatory activities. In vivo, echinacoside inhibits cytochrome c release and caspase-3 activation through modulation of ERK signaling, resulting in neuroprotection in a model of middle cerebral artery occlusion. Echinacoside also displays neuroprotective benefit in a MTPT-induced mouse model of Parkinson’s Disease, decreasing the Bax/Bcl-2 ratio and inhibiting suppression of dopamine and dopamine transporter (DAT) levels. This compound increases cGMP in rat aortic rings, inducing vasodilation. Additionally, echinacoside improves bone mineral density and microarchitecture, decreasing RANKL expression and increasing esteoprotegerin levels in animal models of osteopenia.

Product Info

Cas No.

82854-37-3
Purity

≥98%
Formula

C35H46O20
Formula Wt.

786.73
Chemical Name

[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
IUPAC Name

[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R, 3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R, 6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Solubility

Soluble in water and ethanol.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

E0929 MSDS PDF
Info Sheet

E0929 Info Sheet PDF

References

Yang X, Li F, Yang Y, et al. Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013;2013:926928. PMID: 23573159.

Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80. PMID: 23189969.

Wei LL, Chen H, Jiang Y, et al. Effects of echinacoside on histio-central levels of active mass in middle cerebral artery occlusion rats. Biomed Environ Sci. 2012 Apr;25(2):238-44.PMID: 22998833.

Zhao Q, Gao J, Li W, et al. Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease. Brain Res. 2010 Jul 30;1346:224-36. PMID: 20478277.

He WJ, Fang TH, Ma X, et al. Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway. Planta Med. 2009 Oct;75(13):1400-4. PMID: 19468974.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G124086

    GDC-0152 Free Base

    Promotes degradation of cIAP1

    ≥96%
  • D6108

    1,4-DPCA

    Prolyl hydroxylase inhibitor.

    ≥98%
  • Z324098

    Ziconotide

    Non-opioid analgesic.

    ≥95%
  • C0265

    Carnosic Acid

    Diterpene found in Rosmarinus.

    ≥98%
  • B1654

    Benzyl Selenocyanate

    Organoselenium compound found in selenium-enric...

    ≥98%
  • S8344

    R,S-(±)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥98%
  • V720004

    VS-4718

    Focal adhesion kinase (FAK) inhibitor.

    ≥99%
  • K0117

    Kaempferol

    Flavonol found in various plant sources.

    ≥98%
  • P0001

    P1 Peptide

    Octapeptide, prevents EGFR-PLCγ association.

    ≥95%
  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%
  • A9600

    AZD-3463

    ALK and IGF-1R inhibitor.

    ≥99%
  • S8007

    Substance P (1-7)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • S6235

    Spironolactone

    Mineralocorticoid, aldosterone, AR antagonist, ...

    ≥97%
  • G0181

    Gastrin Releasing Peptide, human

    Endogenous bombesin-like peptide, involved in f...

    ≥95%
  • R1724

    Regadenoson

    Adenosine A2A agonist.

    ≥99%
  • L1983

    Leucomyosuppressin

    Peptide found in insects.

    ≥95%
  • S3453

    Sinigrin Monohydrate, synthetic

    ITC precursor found in cruciferous vegetables.<...

    ≥98%
  • R5773

    Rosiglitazone

    Thiazolidinedione; PPARγ agonist.

    ≥99%
  • H9726

    Hygromycin B

    Protein translocation inhibitor.

    ≥95.0%