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ELR-510444 inhibits microtubule polymerization through binding tubulin at the colchicine site; it exhibits anti-angiogenic and anticancer chemotherapeutic activities. ELR-510444 inhibits cell proliferation and tumor growth in models of breast cancer. In models of renal cell carcinoma, this compound inhibits cell viability, decrease tumor burden, and suppresses expression of HIF-1α.
| Cas No. | 1233948-35-0 |
|---|---|
| Purity | ≥98% |
| Formula | C19H16N2O2S2 |
| Formula Wt. | 368.47 |
| Chemical Name | N-(5-(5-Cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide |
| IUPAC Name | N-[5-(5-Cyano-2-thienyl)-2-methylphenyl]-4-methylbenzenesulfonamide |
| Synonym | AOB6806 |
| Solubility | DMSO: ≥ 37 mg/mL |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Carew JS, Esquivel JA 2nd, Espitia CM, et al. ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. PLoS One. 2012;7(1):e31120. PMID: 22295124.
Risinger AL, Westbrook CD, Encinas A, et al. ELR510444, a novel microtubule disruptor with multiple mechanisms of action. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60. PMID: 21148249.