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Entecavir

Entecavir

Product ID E5576
Cas No. 142217-69-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $49.70 In stock
5 mg $104.80 In stock
25 mg $218.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Entecavir is a cyclopentane class nucleoside analog of deoxyguanosine. Entecavir exhibits antiviral activity and is used clinically to treat hepatitis B infections. Entecavir binds to reverse transcriptase and gets incorporated into DNA, causing chain termination and preventing protein synthesis. This compound may also inhibit HIV-1 reverse transcriptase as well.

Product Info

Cas No.

142217-69-4

Purity

≥97%

Formula

C12H15N5O3

Formula Wt.

277.28

Chemical Name

2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one

IUPAC Name

2-amino-9-[(1S,3R, 4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one

Melting Point

230-240C

Solubility

Water (2-3 mg/ml) DMSO Methanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E5576 MSDS PDF

Info Sheet

E5576 Info Sheet PDF

Brochures

Antivirals Booklet

References

Yurdaydin C. Entecavir: a step forward in combating hepatitis B disease. Expert Opin Pharmacother. 2008 Dec;9(17):3095-109. PMID: 19006481.

Cheng PN, Chang TT. Entecavir: a potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patients. Expert Rev Anti Infect Ther. 2008 Oct;6(5):569-79. PMID: 18847396.

Domaoal RA, McMahon M, Thio CL, et al. Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase. J Biol Chem. 2008 Feb 29;283(9):5452-9. PMID: 17962184.

Langley DR, Walsh AW, Baldick CJ, et al. Inhibition of hepatitis B virus polymerase by entecavir. J Virol. 2007 Apr;81(8):3992-4001. PMID: 17267485.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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