• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
EPZ005687

EPZ005687

Product ID E6396
Cas No. 1396772-26-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $60.10 In stock
5 mg $117.20 In stock
25 mg $390.70 In stock
100 mg $1,172.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers. EPZ-005687 displays anticancer chemotherapeutic activity through its inhibition of EZH2; this enzyme is responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. Inhibition of mutant EZH2 induces apoptosis.

Product Info

Cas No.

1396772-26-1

Purity

≥99%

Formula

C32H37N5O3

Formula Wt.

539.67

Chemical Name

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

IUPAC Name

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

Solubility

DMSO 2 mg/mL (3.7 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6396 MSDS PDF

Info Sheet

E6396 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Knutson SK, Wigle TJ, Warholic NM, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6. PMID: 23023262.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N344784

    N-Nitroso Valsartan

    Valsartan impurity

    ≥98%
  • A0025

    17-Allylaminogeldanamycin

    Geldanamycin derivative; HSP90 inhibitor.

    ≥97%
  • P7060

    Protocatechuic Acid Ethyl Ester

    Dihydroxyphenolic acid found in cruciferous veg...

    ≥98%
  • M0040

    M40

    Peptide; galanin antagonist.

    ≥95%
  • T1670

    Terazosin Hydrochloride Dihydrate

    Quinazoline; α1-adrenergic antagonist.  
    ≥98%
  • L4796

    LY-294002

    PI3K inhibitor.

    ≥99%
  • A0971

    Adrenocorticotropic Hormone (4-10), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • I5830

    Iohexol

    Low osmolarity contrast agent used for imaging ...

    ≥98%
  • Z324098

    Ziconotide

    Non-opioid analgesic.

    ≥95%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • F285081

    Fidaxomicin

    Macrocycle

    ≥98%
  • D1624

    Deflazacort

    Oxazoline; glucocorticoid agonist.

    ≥98%
  • J291331

    JH-II-127

    Selective inhibitor of LRRK2.

    ≥98%
  • M017545

    Manumycin A

    Natural antibiotic found in Streptomyces parvul...

    ≥98%
  • D183744

    Destruxin A

    Cyclic depsipeptide is a secondary metabolite i...

    ≥98%
  • C0264

    L-Carnitine Tartrate

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • I2118

    Ifenprodil Hemitartrate

    NMDA NR1/NR2B antagonist.

    ≥98%
  • T3196

    Thymoquinone

    Phytochemical from Nigella sativa.

    ≥98%
  • K6276

    (E)-KPT-330

    CRM1-selective inhibitor of nuclear export.

    ≥99%
  • C2847

    Chlormadinone Acetate

    Synthetic steroid hormone; AR and ER antagonist...

    ≥96%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only