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EPZ005687

EPZ005687

Product ID E6396
Cas No. 1396772-26-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $60.10 In stock
5 mg $117.20 In stock
25 mg $390.70 In stock
100 mg $1,172.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers. EPZ-005687 displays anticancer chemotherapeutic activity through its inhibition of EZH2; this enzyme is responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. Inhibition of mutant EZH2 induces apoptosis.

Product Info

Cas No.

1396772-26-1

Purity

≥99%

Formula

C32H37N5O3

Formula Wt.

539.67

Chemical Name

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

IUPAC Name

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

Solubility

DMSO 2 mg/mL (3.7 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6396 MSDS PDF

Info Sheet

E6396 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Knutson SK, Wigle TJ, Warholic NM, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6. PMID: 23023262.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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