• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
EPZ005687

EPZ005687

Product ID E6396
Cas No. 1396772-26-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $60.10 In stock
5 mg $117.20 In stock
25 mg $390.70 In stock
100 mg $1,172.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers. EPZ-005687 displays anticancer chemotherapeutic activity through its inhibition of EZH2; this enzyme is responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. Inhibition of mutant EZH2 induces apoptosis.

Product Info

Cas No.

1396772-26-1

Purity

≥99%

Formula

C32H37N5O3

Formula Wt.

539.67

Chemical Name

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

IUPAC Name

1-cyclopentyl-N-[(4, 6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[4-(morpholin-4-ylmethyl) phenyl]indazole-4-carboxamide

Solubility

DMSO 2 mg/mL (3.7 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6396 MSDS PDF

Info Sheet

E6396 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Knutson SK, Wigle TJ, Warholic NM, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6. PMID: 23023262.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • I1400

    Idarubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • A001001

    A 83-01

    TGFbeta receptor inhibitor  
    ≥98%
  • A7200

    AS-252424

    p110γ PI3K inhibitor, potential TRPC1/5/6 nega...

    ≥98%
  • N5605

    Nobiletin

    Polymethoxylated flavone found in citrus fruits...

    ≥97%
  • L0349

    Lamotrigine

    R-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • T2404

    TG101348

    JAK2 inhibitor.

    ≥98%
  • I7074

    Irsogladine Maleate

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • A2420

    A-769662

    AMPK activator.

    ≥98%
  • G0247

    2″O-Galloylhyperin

    Flavonoid glycoside found in Pyrola.

    ≥98%
  • B1769

    Bergenin

    Trihydroxybenzoic acid glycoside found in Berge...

    ≥98%
  • O4672

    Olsalazine Sodium

    5-Aminosalicylate prodrug, NSAID; COX-1/2 inhib...

    ≥98%
  • S3368

    S1RA

    σ1 antagonist.

    ≥99%
  • R1779

    13-cis-Retinoic Acid

    Vitamin A metabolite, differentiation inducer; ...

    97%
  • R2512

    RGD

    Tripeptide, binds cell surface integrins.

    ≥95%
  • L493400

    LMK-235

    Selective HDAC4 and HDAC5 inhibitor.

    ≥98%
  • K0117

    Kaempferol

    Flavonol found in various plant sources.

    ≥98%
  • N5652

    Nonactin

    Naturally-ocurring neurtral cyclic ionophore, m...

    ≥95%, TLC
  • L1684

    Levonorgestrel

    Synthetic progestogen; contraceptive.

    ≥98%
  • C9610

    D-Cycloserine

    NMDA partial agonist, D-Ala-D-Ala ligase inhibi...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only