LKT Labs

Biochemicals for Life Science Research

Eupatilin

Eupatilin

Product ID E8260
Cas No. 22368-21-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $103.00 Please Inquire
25 mg $418.00 Please Inquire
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Description

Eupatilin is an O-methylated flavone found in Artemisia; it exhibits anticancer chemotherapeutic, nephroprotective, anti-inflammatory, anti-arthritic, antinociceptive, gastrointestinal motility modulating, antidepressant, antioxidative, neuroprotective, and anti-angiogenic activities. In gastric cancer cells, eupatilin suppresses cell growth; in animal models of gastric cancer, eupatilin inhibits STAT3 and VEGF expression and decreases tumor growth. This compound activates PPARα and ameliorates kidney injury in models of renal ischemia/reperfusion. Additionally, eupatilin inhibits cartilage degradation, decreases nociception, and downregulates expression of IL-6, iNOS, and IL-1β in animal models of osteoarthritis. Eupatilin also slows gastrointestinal motility in animal models, protects against cerebral ischemia/reperfusion-induced neuronal damage, and decreases immobility time in animals undergoing the forced swim test.

Product Info

Cas No.

22368-21-4
Purity

≥98%
Formula

C18H16O7
Formula Wt.

344.32
Chemical Name

2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
IUPAC Name

2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
Synonym

NSC 122413; Stillen
Solubility

Soluble in DMSO, hot methanol or mixture of methanol and chloroform.
Appearance

Pale yellow powder.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E8260 MSDS PDF
Info Sheet

E8260 Info Sheet PDF

References

Choi Y, Jung Y, Kim SN. Identification of Eupatilin from Artemisia argyi as a Selective PPARα Agonist Using Affinity Selection Ultrafiltration LC-MS. Molecules. 2015 Jul 28;20(8):13753-63. PMID: 26225954.

Jeong JH, Moon SJ, Jhun JY, et al. Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes. PLoS One. 2015 Jun 17;10(6):e0130882. PMID: 26083352.

Jeong HJ, Kim JH, Kim NR, et al. Antidepressant effect of Stillen. Arch Pharm Res. 2015 Jun;38(6):1223-31. PMID: 25163682.

Jeong EK, Jang HJ, Kim SS, et al. Protective effect of eupatilin against renal ischemia-reperfusion injury in mice. Transplant Proc. 2015 Apr;47(3):757-62. PMID: 25891726.

Ryoo SB, Oh HK, Yu SA, et al. The effects of eupatilin (stillen®) on motility of human lower gastrointestinal tracts. Korean J Physiol Pharmacol. 2014 Oct;18(5):383-90. PMID: 25352757.

Park BB, Yoon Js, Kim Es, et al. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. Tumour Biol. 2013 Apr;34(2):875-85. PMID: 23292941.

Lim JC, Park SY, Nam Y, et al. The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells. Korean J Physiol Pharmacol. 2012 Oct;16(5):313-20. PMID: 23118554.

Cai M, Phan PT, Hong JG, et al. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. Eur J Pharmacol. 2012 Aug 15;689(1-3):104-10. PMID: 22683875.

Cheong JH, Hong SY, Zheng Y, et al. Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression. J Gastric Cancer. 2011 Mar;11(1):16-22. PMID: 22076197.

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