• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Eupatilin

Eupatilin

Product ID E8260
Cas No. 22368-21-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.90 Please Inquire
25 mg $417.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Eupatilin is an O-methylated flavone found in Artemisia; it exhibits anticancer chemotherapeutic, nephroprotective, anti-inflammatory, anti-arthritic, antinociceptive, gastrointestinal motility modulating, antidepressant, antioxidative, neuroprotective, and anti-angiogenic activities. In gastric cancer cells, eupatilin suppresses cell growth; in animal models of gastric cancer, eupatilin inhibits STAT3 and VEGF expression and decreases tumor growth. This compound activates PPARα and ameliorates kidney injury in models of renal ischemia/reperfusion. Additionally, eupatilin inhibits cartilage degradation, decreases nociception, and downregulates expression of IL-6, iNOS, and IL-1β in animal models of osteoarthritis. Eupatilin also slows gastrointestinal motility in animal models, protects against cerebral ischemia/reperfusion-induced neuronal damage, and decreases immobility time in animals undergoing the forced swim test.

Product Info

Cas No.

22368-21-4

Purity

≥98%

Formula

C18H16O7

Formula Wt.

344.32

Chemical Name

2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one

IUPAC Name

2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one

Synonym

NSC 122413; Stillen

Solubility

Soluble in DMSO, hot methanol or mixture of methanol and chloroform.

Appearance

Pale yellow powder.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E8260 MSDS PDF

Info Sheet

E8260 Info Sheet PDF

References

Choi Y, Jung Y, Kim SN. Identification of Eupatilin from Artemisia argyi as a Selective PPARα Agonist Using Affinity Selection Ultrafiltration LC-MS. Molecules. 2015 Jul 28;20(8):13753-63. PMID: 26225954.

Jeong JH, Moon SJ, Jhun JY, et al. Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes. PLoS One. 2015 Jun 17;10(6):e0130882. PMID: 26083352.

Jeong HJ, Kim JH, Kim NR, et al. Antidepressant effect of Stillen. Arch Pharm Res. 2015 Jun;38(6):1223-31. PMID: 25163682.

Jeong EK, Jang HJ, Kim SS, et al. Protective effect of eupatilin against renal ischemia-reperfusion injury in mice. Transplant Proc. 2015 Apr;47(3):757-62. PMID: 25891726.

Ryoo SB, Oh HK, Yu SA, et al. The effects of eupatilin (stillen®) on motility of human lower gastrointestinal tracts. Korean J Physiol Pharmacol. 2014 Oct;18(5):383-90. PMID: 25352757.

Park BB, Yoon Js, Kim Es, et al. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. Tumour Biol. 2013 Apr;34(2):875-85. PMID: 23292941.

Lim JC, Park SY, Nam Y, et al. The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells. Korean J Physiol Pharmacol. 2012 Oct;16(5):313-20. PMID: 23118554.

Cai M, Phan PT, Hong JG, et al. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. Eur J Pharmacol. 2012 Aug 15;689(1-3):104-10. PMID: 22683875.

Cheong JH, Hong SY, Zheng Y, et al. Eupatilin Inhibits Gastric Cancer Cell Growth by Blocking STAT3-Mediated VEGF Expression. J Gastric Cancer. 2011 Mar;11(1):16-22. PMID: 22076197.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • G5874

    Gossypol

    Polyphenol found in Gossypium; calcineurin and ...

    ≥98%
  • W0269

    (±)-Warfarin

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • M5794

    Moxifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV, topoisomeras...

    ≥98%
  • A851322

    Avibactam Sodium

    Diazabicyclooctane β-lactamase inhibitor.

    ≥98%
  • O2144

    Ofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C5768

    Corazonin

    Neuropeptide found in insects.

    ≥95%
  • A1202

    Adapalene

    Tretinoin analog; RARα/β/γ agonist.

    ≥98%
  • E7731

    17-α-Ethynylestradiol

    Synthetic steroid hormone; ER agonist.

    ≥99%
  • H1662

    HER2/neu (654-662) GP2

    Peptide fragment of HER2/neu/erbB2 receptor.

    ≥95%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...

  • B8363

    Bupropion Hydrochloride

    α3β2, α3β4, α4β2 nAChR antagonist, indire...

    ≥98%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • P1764

    Pep-1 Peptide

    Cell-penetrating peptide, carries large conjuga...

    ≥95%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%
  • S680017

    SR-717 Lithium Salt

    STING agonist

    ≥98%
  • P2304

    Phalloidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥90%
  • H1894

    Hexestrol

    Synthetic catechol; ER agonist, microtubule pol...

    ≥98%
  • C1632

    Cefotaxime Acid

    β-lactam cephalosporin; penicillin binding pro...

    ≥91%
  • P2002

    PF-04691502 Dihydrate

    PI3K and mTOR inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only