Description
Eupatilin is an O-methylated flavone found in Artemisia; it exhibits anticancer chemotherapeutic, nephroprotective, anti-inflammatory, anti-arthritic, antinociceptive, gastrointestinal motility modulating, antidepressant, antioxidative, neuroprotective, and anti-angiogenic activities. In gastric cancer cells, eupatilin suppresses cell growth; in animal models of gastric cancer, eupatilin inhibits STAT3 and VEGF expression and decreases tumor growth. This compound activates PPARα and ameliorates kidney injury in models of renal ischemia/reperfusion. Additionally, eupatilin inhibits cartilage degradation, decreases nociception, and downregulates expression of IL-6, iNOS, and IL-1β in animal models of osteoarthritis. Eupatilin also slows gastrointestinal motility in animal models, protects against cerebral ischemia/reperfusion-induced neuronal damage, and decreases immobility time in animals undergoing the forced swim test.