LKT Labs

Biochemicals for Life Science Research

EX-527

EX-527

Product ID E9201
Cas No. 49843-98-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $292.00 In stock
Bulk Quote

Quicklinks

Description

EX-527 is an inhibitor of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). EX-527 binds the NAD+ site of sirtuin 1, stabilizing a closed conformation. EX-527 exhibits immunostimulatory and anti-inflammatory activities. In animal models of autoimmune colitis and inflammatory bowel disease, EX-527 increases the number of Foxp3+ Treg cells and prevents weight loss. In animal models of polycystic kidney disease, this compound delays renal cyst formation and growth. Additionally, EX-527 improves myocardial histology and increases the number of Foxp3+ Treg cells in animal models of transplant surgery, prolonging allograft survival.

Product Info

Cas No.

49843-98-3
Purity

≥99%
Formula

C13H13ClN2O
Formula Wt.

248.71
IUPAC Name

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonym

Selisistat
Solubility

DMSO 49 mg/mL (197.01 mM) Ethanol 18 mg/mL (72.37 mM) Water Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E9201 MSDS PDF
Info Sheet

E9201 Info Sheet PDF

References

Akimova T, Xiao H, Liu Y, et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol. 2014 Feb 19. [Epub ahead of print]. PMID: 24549276.

Gertz M, Fischer F, Nguyen GT, et al. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. PMID: 23840057.

Zhou X, Fan LX, Sweeney WE Jr, et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul 1;123(7):3084-98. PMID: 23778143.

Beier UH, Wang L, Bhatti TR, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. PMID: 21199917.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L4796

    LY-294002

    PI3K inhibitor.

    ≥99%
  • S5868

    Sorafenib

    c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...

    ≥98%
  • S1609

    Securinine

    Alkaloid found in Securinega; potential GABA-A ...

    ≥98%
  • E6781

    (±)-Equol

    Isoflavone, phytoestrogen found in soy; ER agon...

    ≥98%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • C344761

    Citalopram Chloromethyl Quaternary Ammonium Chloride

    Citalopram analog

    ≥95%
  • H9814

    25-Hydroxyvitamin D2

    Vitamin D2, ergocalciferol metabolite; VDR agon...

    ≥98%
  • K1678

    Ketanserin

    5-HT2A antagonist, potential α1-adrenergic ant...

    ≥97%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • A064766

    ABT 639

    T-type calcium channel blocker

    ≥99%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • A5234

    Amisulpride

    5-HT7 and D2/3 antagonist.

    ≥98%
  • V344766

    Vitexin

    Found in hawthorn.

    ≥98%
  • A4802

    Amantadine Hydrochloride

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • L493400

    LMK-235

    Selective HDAC4 and HDAC5 inhibitor.

    ≥98%
  • A0902

    N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant; HDAC inhib...

    ≥98%
  • A0776

    ABT-199

    BH3 mimetic; Bcl-2 inhibitor.

    ≥99%
  • E846182

    Everolimus EP Impurity E

    Impurity of everolimus

    ≥80%
  • D5746

    Dolasetron

    5-HT3 antagonist.

    ≥98%