EX-527

Name: EX-527
SKU: E9201
Availability: InStock

Product ID E9201

Cas No. 49843-98-3

Purity ≥99%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

EX-527 is an inhibitor of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). EX-527 binds the NAD+ site of sirtuin 1, stabilizing a closed conformation. EX-527 exhibits immunostimulatory and anti-inflammatory activities. In animal models of autoimmune colitis and inflammatory bowel disease, EX-527 increases the number of Foxp3+ Treg cells and prevents weight loss. In animal models of polycystic kidney disease, this compound delays renal cyst formation and growth. Additionally, EX-527 improves myocardial histology and increases the number of Foxp3+ Treg cells in animal models of transplant surgery, prolonging allograft survival.

Product Info

Cas No.	49843-98-3
Purity	≥99%
Formula	C₁₃H₁₃ClN₂O
Formula Wt.	248.71
IUPAC Name	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonym	Selisistat
Solubility	DMSO 49 mg/mL (197.01 mM) Ethanol 18 mg/mL (72.37 mM) Water Insoluble
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	E9201 MSDS PDF
Info Sheet	E9201 Info Sheet PDF

References

Akimova T, Xiao H, Liu Y, et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol. 2014 Feb 19. [Epub ahead of print]. PMID: 24549276.

Gertz M, Fischer F, Nguyen GT, et al. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. PMID: 23840057.

Zhou X, Fan LX, Sweeney WE Jr, et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul 1;123(7):3084-98. PMID: 23778143.

Beier UH, Wang L, Bhatti TR, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. PMID: 21199917.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

EX-527

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Bis(3,5-dibromosalicyl) Fumarate

ATB 346

PF-03758309 Dihydrochloride

Gastrin I, human

(±)-Warfarin

Ginsenoside Rb1

RGDV

Mastoparan 17

J-147

CCT-196969

Tedizolid

Bradykinin (1-7)

Orbifloxacin

Recombinant HCV-Core Antigens

E64-d

Meleagrin

D-(+)-Neopterin

Dasatinib

Pifithrin-α Hydrobromide

Acepromazine Maleate

Footer