• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
EX-527

EX-527

Product ID E9201
Cas No. 49843-98-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $292.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

EX-527 is an inhibitor of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). EX-527 binds the NAD+ site of sirtuin 1, stabilizing a closed conformation. EX-527 exhibits immunostimulatory and anti-inflammatory activities. In animal models of autoimmune colitis and inflammatory bowel disease, EX-527 increases the number of Foxp3+ Treg cells and prevents weight loss. In animal models of polycystic kidney disease, this compound delays renal cyst formation and growth. Additionally, EX-527 improves myocardial histology and increases the number of Foxp3+ Treg cells in animal models of transplant surgery, prolonging allograft survival.

Product Info

Cas No.

49843-98-3

Purity

≥99%

Formula

C13H13ClN2O

Formula Wt.

248.71

IUPAC Name

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Synonym

Selisistat

Solubility

DMSO 49 mg/mL (197.01 mM) Ethanol 18 mg/mL (72.37 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E9201 MSDS PDF

Info Sheet

E9201 Info Sheet PDF

References

Akimova T, Xiao H, Liu Y, et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol. 2014 Feb 19. [Epub ahead of print]. PMID: 24549276.

Gertz M, Fischer F, Nguyen GT, et al. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. PMID: 23840057.

Zhou X, Fan LX, Sweeney WE Jr, et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul 1;123(7):3084-98. PMID: 23778143.

Beier UH, Wang L, Bhatti TR, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. PMID: 21199917.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G6803

    Granuliberin R

    Antimicrobial peptide found in amphibians.

    ≥95%
  • E6432

    (−)-Epinephrine

    Active isomer of epinephrine, endogenous hormon...

    ≥98%
  • R7680

    Recombinant M. Tuberculosis Antigen TB 38+6+10

    Tuberculosis antigen

  • B8073

    4-tert-Butyl-5-Methoxycatechol

    BHA derivative.

    ≥98%
  • T5944

    Tolmetin Sodium

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • V3251

    Vinorelbine Base

    Semi-synthetic vinca alkaloid found in Catharan...

    ≥90%
  • I611325

    IPI-549

    Selective inhibitor of the γ isoform of PI3K (...

    ≥98%
  • G3459

    Ginsenoside Rg2

    Triterpene saponin found in species of Panax.

    ≥98%
  • H9714

    L-5-Hydroxytryptophan

    Endogenous amino acid, precursor of 5-HT and me...

    ≥98%
  • C1650

    β-Cembrenediol Methyl Ether

    Diterpene found in tobacco plants and cigarette...

    ≥98%
  • N3228

    Nifedipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • P3018

    Phellodendrine

    Quaternary base alkaloid found in Phellodendron...

    ≥98%
  • K0282

    Kavalactones Mixture

    Mixture of kavalactones found in Piper methysti...

    ≥98%
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • H0002

    H8 dihydrochloride

    PKA inhibitor.

    ≥98%
  • S8044

    R,S-Sulforaphane, High Purity

    Phase II enzyme inducer; Nrf2 activator; antiox...

    ≥99%
  • E6782

    S-Equol

    Isoflavone, phytoestrogen found in soy; ER agon...

    ≥99%
  • T7031

    Triflumuron

    Insect growth regulator; chitin synthesis inhib...

    ≥98%
  • H9612

    Hydrocortisone 21-Acetate

    Steroid hormone involved in stress signaling; g...

    ≥98%
  • C2946

    Chlorambucil

    Nitrogen mustard, DNA alkylator.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only