LKT Labs

Biochemicals for Life Science Research

EX-527

EX-527

Product ID E9201
Cas No. 49843-98-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $292.00 In stock
Bulk Quote

Quicklinks

Description

EX-527 is an inhibitor of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). EX-527 binds the NAD+ site of sirtuin 1, stabilizing a closed conformation. EX-527 exhibits immunostimulatory and anti-inflammatory activities. In animal models of autoimmune colitis and inflammatory bowel disease, EX-527 increases the number of Foxp3+ Treg cells and prevents weight loss. In animal models of polycystic kidney disease, this compound delays renal cyst formation and growth. Additionally, EX-527 improves myocardial histology and increases the number of Foxp3+ Treg cells in animal models of transplant surgery, prolonging allograft survival.

Product Info

Cas No.

49843-98-3
Purity

≥99%
Formula

C13H13ClN2O
Formula Wt.

248.71
IUPAC Name

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonym

Selisistat
Solubility

DMSO 49 mg/mL (197.01 mM) Ethanol 18 mg/mL (72.37 mM) Water Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E9201 MSDS PDF
Info Sheet

E9201 Info Sheet PDF

References

Akimova T, Xiao H, Liu Y, et al. Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol. 2014 Feb 19. [Epub ahead of print]. PMID: 24549276.

Gertz M, Fischer F, Nguyen GT, et al. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. PMID: 23840057.

Zhou X, Fan LX, Sweeney WE Jr, et al. Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. J Clin Invest. 2013 Jul 1;123(7):3084-98. PMID: 23778143.

Beier UH, Wang L, Bhatti TR, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol. 2011 Mar;31(5):1022-9. PMID: 21199917.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A761003

    AT-7519 Hydrochloride

    ATP competitive CDK inhibitor.

    ≥98%
  • R2353

    RF-NH2

    RF-amide peptide; potential GPR147 agonist, pot...

    ≥95%
  • T1679

    Tetracycline Hydrochloride

    Polyketide; protein translation inhibitor, mamm...

    ≥95%
  • S801001

    SU-5402

    Inhibitor of VEGFR and FGFR.

    ≥98%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%
  • L2540

    LGK-974

    PORCN inhibitor.

    ≥98%
  • H189921

    1,2,3,4,5,6-Hexabromocyclohexane

    JAK2 inhibitor

    ≥98%
  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%
  • M721002

    MSA-2

    STING agonist

    ≥98%
  • A990144

    AZD4320

    Inhibitor of Bcl-2 and Bcl-xL

    ≥99%
  • C4757

    Clozapine

    M4 mAChR agonist, 5-HT1A partial agonist, M1/2/...

    ≥97%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • M4102

    MK-1775

    Wee1 inhibitor.

    ≥98%
  • T564092

    γ-Tocopherol

    Vitamin E component

    ≥98%
  • C5768

    Corazonin

    Neuropeptide found in insects.

    ≥95%
  • M4455

    MLN-2238

    Proteasome inhibitor, miR33b modulator.

    ≥95%
  • D1621

    Deferasirox

    Iron chelator.

    ≥99%
  • L8261

    Lupeol

    Triterpene; potential tyrosinase inhibitor.

    ≥98%
  • E5210

    Endomorphin-1

    Endogenous opioid peptide; μOr agonist.

    ≥95%
  • S0033

    Saikosaponin B2

    Saponin found in Bupleurum, Heteromorpha, and S...

    ≥98%