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Exemestane

Exemestane

Product ID E9317
Cas No. 107868-30-4
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $102.00 In stock
100 mg $306.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Exemestane is a third generation aromatase inhibitor that prevents estrogen synthesis and is clinically used to treat ER+ breast cancer. Exemestane exhibits anticancer chemotherapeutic activity, inhibiting proliferation and inducing cell cycle arrest, apoptosis, and autophagy in breast cancer cells.

Product Info

Cas No.

107868-30-4

Purity

≥97%

Formula

C20H24O2

Formula Wt.

296.40

Chemical Name

6-Methyleneandrosta-1,4-diene-3,17-dione

IUPAC Name

(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15, 16-octahydrocyclopenta[a]phenanthrene-3,17-dione

Synonym

Aromasin, FCE-24304

Melting Point

188-191°C

Solubility

Soluble in methanol, ethanol (15 mg/mL), DMSO (54mg/mL) or dimethylformamide. Insoluble in water.

Appearance

Yellowish to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E9317 MSDS PDF

Info Sheet

E9317 Info Sheet PDF

References

Amaral C, Borges M, Melo S, et al. Apoptosis and autophagy in breast cancer cells following exemestane treatment. PLoS One. 2012;7(8):e42398. PMID: 22912703.

Hong Y, Rashid R, Chen S. Binding features of steroidal and nonsteroidal inhibitors. Steroids. 2011 Jul;76(8):802-6. PMID: 21420422.

Bertelli G, Hall E, Ireland E, et al. Long-term endometrial effects in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES)--a randomised controlled trial of exemestane versus continued tamoxifen after 2-3 years tamoxifen. Ann Oncol. 2010 Mar;21(3):498-505. PMID: 19717534.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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