• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Fingolimod Hydrochloride

Fingolimod Hydrochloride

Product ID F3454
Cas No. 162359-56-0
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $45.30 In stock
25 mg $67.80 In stock
100 mg $210.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fingolimod is an inhibitor of sphingosine 1-phosphate receptors that is used clinically as a treatment for autoimmune diseases such as multiple sclerosis; this compound prevents movement of autoreactive lymphocytes from the lymph nodes into circulation. Fingolimod exhibits immunosuppressive, neuroprotective, and anticancer chemotherapeutic benefits. In Treg cells, fingolimod increases levels of TGF- β1 and Foxp3. In in vitro and in vivo models of Alzheimer’s disease, this compound decreases production of amyloid-β (Aβ) proteins. Additionally, fingolimod inhibits expression of sphingosine kinase 2 and increases cell death in neuroblastoma cells. Fingolimod inhibits growth of cancerous xenografts in vivo as well.

Product Info

Cas No.

162359-56-0

Purity

≥99%

Formula

C19H32NO2 • HCl

Formula Wt.

343.93

Chemical Name

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

IUPAC Name

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride

Synonym

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride, FTY720.HCl

Melting Point

107-108°

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F3454 MSDS PDF

Info Sheet

F3454 Info Sheet PDF

References

Li MH, Hla T, Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer. 2013 Sep;60(9):1418-23. PMID: 23704073.

Takasugi N, Sasaki T, Ebinuma I, et al. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. PLoS One. 2013 May 7;8(5):e64050. PMID: 23667698.

Groves A, Kihara Y, Chun J. Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci. 2013 May 15;328(1-2):9-18. PMID: 23518370.

Willis MA, Cohen JA. Fingolimod therapy for multiple sclerosis. Semin Neurol. 2013 Feb;33(1):37-44. PMID: 23709211.

Liu Y, Jiang J, Xiao H, et al. The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro. Int J Mol Med. 2012 Jul;30(1):211-9. PMID: 22576630.

Spijkers LJ, Alewijnse AE, Peters SL. FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase. Br J Pharmacol. 2012 Jun;166(4):1411-8. PMID: 22251137.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G4518

    Glucaric Acid Calcium Tetrahydrate

    Oxidized non-cylic hexose sugar.

    ≥98%
  • E7433

    Etidronate Disodium

    Bisphosphonate, chelating agent.

    ≥98%
  • G2969

    Growth Hormone Releasing Hexapeptide

    Synthetic peptide hormone, met-enkephalin analo...

    ≥95%
  • J3204

    E-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • T3568

    Tirasemtiv

    Fast skeletal muscle troponin complex activator...

    ≥99%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • A5059

    Amoxapine

    5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenerg...

    ≥98%
  • C2950

    Chloroquine Diphosphate

    Aminoquinoline, binds heme, causes cell lysis.<...

    ≥98%
  • C4646

    Clofarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • B3358

    Biochanin A

    Phytoestrogen, flavonoid found in clover, soy, ...

    ≥98%
  • C0048

    Cambinol

    SIRT inhibitor.

    ≥98%
  • I4962

    Isoimperatorin

    Furocoumarin; COX-2 inhibitor.

    ≥98%
  • D1644

    Deltorphin I

    Opioid peptide; δOR agonist.

    ≥98%
  • L3455

    α-Linolenic Acid

    An omega-3 fatty acid.

    ≥98%
  • A4845

    Amylin (8-37), rat

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • C0376

    Catharanthine base

    Alkaloid found in Catharanthus, precursor in sy...

    ≥98%
  • A5030

    4-Aminophenylphosphate Monosodium

    Alkaline phosphatase substrate used to quantify...

    ≥97%
  • E537334

    Enniatin B

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • I7256

    Isobavachalcone

    Prenylated chalcone flavonoid found in Psoralea...

    ≥97%
  • P0255

    Pantoprazole

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only