• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Fingolimod Hydrochloride

Fingolimod Hydrochloride

Product ID F3454
Cas No. 162359-56-0
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $45.30 In stock
25 mg $67.80 In stock
100 mg $210.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fingolimod is an inhibitor of sphingosine 1-phosphate receptors that is used clinically as a treatment for autoimmune diseases such as multiple sclerosis; this compound prevents movement of autoreactive lymphocytes from the lymph nodes into circulation. Fingolimod exhibits immunosuppressive, neuroprotective, and anticancer chemotherapeutic benefits. In Treg cells, fingolimod increases levels of TGF- β1 and Foxp3. In in vitro and in vivo models of Alzheimer’s disease, this compound decreases production of amyloid-β (Aβ) proteins. Additionally, fingolimod inhibits expression of sphingosine kinase 2 and increases cell death in neuroblastoma cells. Fingolimod inhibits growth of cancerous xenografts in vivo as well.

Product Info

Cas No.

162359-56-0

Purity

≥99%

Formula

C19H32NO2 • HCl

Formula Wt.

343.93

Chemical Name

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

IUPAC Name

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride

Synonym

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride, FTY720.HCl

Melting Point

107-108°

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F3454 MSDS PDF

Info Sheet

F3454 Info Sheet PDF

References

Li MH, Hla T, Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer. 2013 Sep;60(9):1418-23. PMID: 23704073.

Takasugi N, Sasaki T, Ebinuma I, et al. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. PLoS One. 2013 May 7;8(5):e64050. PMID: 23667698.

Groves A, Kihara Y, Chun J. Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci. 2013 May 15;328(1-2):9-18. PMID: 23518370.

Willis MA, Cohen JA. Fingolimod therapy for multiple sclerosis. Semin Neurol. 2013 Feb;33(1):37-44. PMID: 23709211.

Liu Y, Jiang J, Xiao H, et al. The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro. Int J Mol Med. 2012 Jul;30(1):211-9. PMID: 22576630.

Spijkers LJ, Alewijnse AE, Peters SL. FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase. Br J Pharmacol. 2012 Jun;166(4):1411-8. PMID: 22251137.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C600000

    CP 55940

    Non-selective CB receptor agonist.

    ≥97%
  • T5944

    Tolmetin Sodium

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • M184776

    5-(Methylsulfonyl)pentyl Nitrile

    Synthetic nitrile compound

    ≥98%
  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • L0211

    Lactulose

    Synthetic non-digestible disaccharide.

    ≥99%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • C7097

    Cryptotanshinone

    Quinoid diterpene found in species of Salvia; S...

    ≥90%
  • T0102

    7-epi-Taxol

    Taxane found in Taxus; potential microtubule de...

    ≥95%
  • C4417

    Clemizole

    TRPC5 activator, NS4B and histamine H1 inhibito...

    ≥98%
  • P005095

    N-Debenzoylpaclitaxel

    Paclitaxel derivative

    ≥95%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • R4132

    RKI-1447

    ROCK1/2 inhibitor.

    ≥98%
  • A4496

    Alyssin

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • A4805

    Amastatin Hydrochloride Hydrate

    Aminopeptidase inhibitor.

    ≥98%
  • U6802

    Urapidil Hydrochloride

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • C0800

    C59

    PORCN inhibitor.

    ≥98%
  • J3204

    E-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • H8162

    (−)-Huperzine A

    Sesquiterpene alkaloid found in Huperzia serrat...

    ≥97%
  • N3422

    Nifekalant Hydrochloride

    Voltage-gated K+ channel blocker.

    ≥98%
  • R2811

    Recombinant HIV-1 gp-41

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only