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Fluticasone Propionate

Fluticasone Propionate

Product ID F4683
Cas No. 80474-14-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $141.00 In stock
25 mg $281.60 In stock
100 mg $915.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fluticasone is an agonist at β2-adrenergic receptors that is clinically used to treat asthma and COPD; it exhibits anti-inflammatory, vasodilatory, anti-asthma, and anti-allergic activities. In airway epithelial cells, fluticasone increases expression of IκB kinase, preventing activation of NF-κB. In other in vitro models, fluticasone decreases lymphocyte activation, particularly mast cell activation, and decreases IL-6 levels. In animal models, fluticasone upregulates Smad7 and downregulates phospho-Smad2/3 and TGF-β1 levels, preventing eosinophilic inflammation and airway remodeling.

Product Info

Cas No.

80474-14-2

Purity

≥98%

Formula

C25H31F3O5S

Formula Wt.

500.57

IUPAC Name

[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6, 9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13, 16-trimethyl-3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Melting Point

272-273°C

Solubility

10 mg/ml DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4683 MSDS PDF

Info Sheet

F4683 Info Sheet PDF

References

Kan-O K, Matsumoto K, Inoue H, et al. Corticosteroids plus long-acting β2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium. Int Arch Allergy Immunol. 2013;160(1):27-36. PMID: 22948082.

Mendes ES, Horvath G, Campos M, et al. Rapid corticosteroid effect on beta(2)-adrenergic airway and airway vascular reactivity in patients with mild asthma. J Allergy Clin Immunol. 2008 Mar;121(3):700-4. PMID: 18086493.

Lee SY, Kim JS, Lee JM, et al. Inhaled corticosteroid prevents the thickening of airway smooth muscle in murine model of chronic asthma. Pulm Pharmacol Ther. 2008;21(1):14-9. PMID: 17142077.

Edwards MR, Haas J, Panettieri RA Jr, et al. Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J Biol Chem. 2007 May 25;282(21):15366-75. PMID: 17395587.

Booth H, Richmond I, Ward C, et al. Effect of high dose inhaled fluticasone propionate on airway inflammation in asthma. Am J Respir Crit Care Med. 1995 Jul;152(1):45-52. PMID: 7599861.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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