• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Fotemustine

Fotemustine

Product ID F5976
Cas No. 92118-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $88.10 In stock
25 mg $201.20 In stock
100 mg $503.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fotemustine is a chloroethylnitrosourea that exhibits anticancer chemotherapeutic benefit. Fotemustine alkylates or induces cross-links in DNA, halting cell cycle progression at the G2/M phase and inhibiting DNA repair mechanisms. Fotemustine displays greater cytotoxicity in methyl excision repair-deficient cells, indicating its primary site of alkylation is the O6 site of guanine bases. Fotemustine may also deactivate thioredoxin reductase, glutathione reductase, and ribonucleotide reductase by alkylating their thiol active sites.

Product Info

Cas No.

92118-27-9

Purity

≥98%

Formula

C9H19ClN3O5P

Formula Wt.

315.69

Chemical Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea

IUPAC Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea

Synonym

Mustophorane; Muphoran

Appearance

Light yellow

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

F5976 MSDS PDF

Info Sheet

F5976 Info Sheet PDF

References

Hayes MT, Bartley J, Parsons PG. In vitro evaluation of fotemustine as a potential agent for limb perfusion in melanoma. Melanoma Res. 1998 Feb;8(1):67-75. PMID: 9508380.

Hayes MT, Bartley J, Parsons PG, et al. Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity. Biochemistry. 1997 Sep 2;36(35):10646-54. PMID: 9271495.

Schallreuter KU, Gleason FK, Wood JM. The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. Biochim Biophys Acta. 1990 Aug 13;1054(1):14-20. PMID: 2200526.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • N0212

    Nedaplatin

    Pt-based DNA cross-linker.

    ≥98%
  • P2845

    Phleomycin

    Glycopeptide, metal ion chelator, induces DNA stra...
    ≥97%
  • S6232

    Spiramycin

    Macrolide; protein synthesis inhibitor. ≥3900...

    ≥3900 IU/mg
  • L1784

    Levetiracetam

    SV2A synaptic vesicle inhibitor.

    ≥99%
  • C0273

    Casin

    Cdc42 GTPase inhibitor.

    ≥97%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • P9870

    Pyridostatin Hydrochloride

    G-quadruplex ligand; DNA breakage inducer.

    ≥97%
  • A7672

    Atropine Sulfate Monohydrate

    Tropane alkaloid found in Solanaceae plants; mA...

    ≥98%
  • T1953

    Tenovin-3

    Potential p53 activator or SIRT2 inhibitor.

    ≥98%
  • A5287

    Angiotensinogen (1-14), human

    Peptide fragment, renin substrate, precursor to...

    ≥95%
  • D336486

    Dimethylamino Parthenolide

    Water-soluble parthenolide analog; NF-κB inhib...

    ≥98%
  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.

    ≥98%
  • C017521

    Canagliflozin

    SGLT2 inhibitor

    ≥98%
  • O0830

    Ochratoxin B

    Non-chlorinated analogue of the mycotoxin Ochra...

    ≥99%
  • K9200

    KX1-004

    Indole; Src inhibitor.

    ≥98%
  • T0108

    10-Deacetyl-7-xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • T2800

    Thalidomide

    Immunomodulator; teratogen.

    ≥98%
  • R2511

    RGDC

    Peptide, used to study cell-surface binding; po...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only