• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Fotemustine

Fotemustine

Product ID F5976
Cas No. 92118-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $88.10 In stock
25 mg $201.20 In stock
100 mg $503.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Fotemustine is a chloroethylnitrosourea that exhibits anticancer chemotherapeutic benefit. Fotemustine alkylates or induces cross-links in DNA, halting cell cycle progression at the G2/M phase and inhibiting DNA repair mechanisms. Fotemustine displays greater cytotoxicity in methyl excision repair-deficient cells, indicating its primary site of alkylation is the O6 site of guanine bases. Fotemustine may also deactivate thioredoxin reductase, glutathione reductase, and ribonucleotide reductase by alkylating their thiol active sites.

Product Info

Cas No.

92118-27-9

Purity

≥98%

Formula

C9H19ClN3O5P

Formula Wt.

315.69

Chemical Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea

IUPAC Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea

Synonym

Mustophorane; Muphoran

Appearance

Light yellow

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

F5976 MSDS PDF

Info Sheet

F5976 Info Sheet PDF

References

Hayes MT, Bartley J, Parsons PG. In vitro evaluation of fotemustine as a potential agent for limb perfusion in melanoma. Melanoma Res. 1998 Feb;8(1):67-75. PMID: 9508380.

Hayes MT, Bartley J, Parsons PG, et al. Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity. Biochemistry. 1997 Sep 2;36(35):10646-54. PMID: 9271495.

Schallreuter KU, Gleason FK, Wood JM. The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. Biochim Biophys Acta. 1990 Aug 13;1054(1):14-20. PMID: 2200526.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V1854

    Venlafaxine Hydrochloride

    SERT, NET, MAO inhibitor.

    ≥98%
  • C022692

    Carbinoxamine Maleate

    Histamine H1-antagonist

    ≥98%
  • O7218

    Oseltamivir Phosphate

    Viral neuraminidase inhibitor, potential MAO-A ...

    ≥98%
  • L582694

    Lorlatinib

    Third generation macrocyclic ALK inhibitor.

    ≥98%
  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • M9646

    Myelin Basic Protein (68-82), guinea pig

    Immunodominant peptide epitope occurring in mul...

    ≥95%
  • A9712

    AZD-6482

    p110β PI3K inhibitor.

    ≥98%
  • D0261

    Dapivirine

    RT inhibitor.

    ≥98%
  • J889290

    JWH 133

    Cannabinoid receptor 2 selective agonist.

    ≥95%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • D5662

    Dopamine Hydrochloride

    Endogenous hormone neurotransmitter, involved i...

    ≥99%
  • G8101

    Guaifenesin

    Expectorant.

    ≥98%
  • E5210

    Endomorphin-1

    Endogenous opioid peptide; μOr agonist.

    ≥95%
  • S3033

    Shikimic Acid

    Cyclohexanecarboxylic acid found in various pla...

    ≥98%
  • P0006

    Pituitary Adenylate Cyclase-activating Polypeptide (1-38), human, sheep, rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • A7071

    Atriopeptin II, rat/rabbit/mouse

    ANP analog, cardiomodulatory peptide; NPR-A ago...

    ≥95%
  • P2410

    Phenethyl Dimethyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • S0072

    5S rRNA modificator

    Electrophile used in 2’-hydroxyl acylation of...

    ≥98%
  • N8277

    Nutlin-3

    Imidzoline derivative; MDM2 inhibitor.

    ≥95%
  • R0247

    Raltegravir

    HIV integrase inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only