LKT Labs

Biochemicals for Life Science Research

Fotemustine

Fotemustine

Product ID F5976
Cas No. 92118-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $88.10 In stock
25 mg $201.20 In stock
100 mg $503.40 In stock
Bulk Quote

Quicklinks

Description

Fotemustine is a chloroethylnitrosourea that exhibits anticancer chemotherapeutic benefit. Fotemustine alkylates or induces cross-links in DNA, halting cell cycle progression at the G2/M phase and inhibiting DNA repair mechanisms. Fotemustine displays greater cytotoxicity in methyl excision repair-deficient cells, indicating its primary site of alkylation is the O6 site of guanine bases. Fotemustine may also deactivate thioredoxin reductase, glutathione reductase, and ribonucleotide reductase by alkylating their thiol active sites.

Product Info

Cas No.

92118-27-9
Purity

≥98%
Formula

C9H19ClN3O5P
Formula Wt.

315.69
Chemical Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
IUPAC Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
Synonym

Mustophorane; Muphoran
Appearance

Light yellow

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F5976 MSDS PDF
Info Sheet

F5976 Info Sheet PDF

References

Hayes MT, Bartley J, Parsons PG. In vitro evaluation of fotemustine as a potential agent for limb perfusion in melanoma. Melanoma Res. 1998 Feb;8(1):67-75. PMID: 9508380.

Hayes MT, Bartley J, Parsons PG, et al. Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity. Biochemistry. 1997 Sep 2;36(35):10646-54. PMID: 9271495.

Schallreuter KU, Gleason FK, Wood JM. The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. Biochim Biophys Acta. 1990 Aug 13;1054(1):14-20. PMID: 2200526.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T9968

    Tyrphostin A25

    SK K+ channel blocker, EGFR inhibitor.

    ≥98%
  • A686164

    Arecaidine Hydrochloride

    mAChR agonist, selective for M2.

    ≥98%
  • C4532

    Clindamycin Hydrochloride

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • A0978

    Actinonin

    Peptide deformylase, MMP meprin A, aminopeptida...

    ≥98%
  • B1603

    Beauvericin

    Cyclic hexadepsipeptide mycotoxin produced by C...

    ≥95%
  • I5315

    Indomethacin

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B560000

    RAD51 inhibitor, B02

    RAD51 inhibitor.

    ≥98%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • P6865

    Propranolol Hydrochloride

    β1/2-adrenergic antagonist.

    ≥98%
  • C4402

    Cladribine

    Nucleoside (deoxyadenosine) analog; DNA chain t...

    ≥98%
  • P2522

    S-(N-Phenylthiocarbamoyl)-glutathione

    Glutathione-ITC conjugate, antioxidant.

    ≥98%
  • R5992

    Roxithromycin

    Macrolide; protein synthesis inhibitor.

    ≥96%
  • P1622

    Pefloxacin Methanesulfonate Dihydrate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C0377

    Catharanthine Sulfate

    Alkaloid found in Catharanthus, precursor in sy...

    ≥98%
  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • I6933

    Irinotecan Hydrochloride Trihydrate

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • K0053

    Kanamycin A Monosulfate

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%