LKT Labs

Biochemicals for Life Science Research

Fotemustine

Product ID F5976
Cas No. 92118-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $83.90 In stock
25 mg $191.60 In stock
100 mg $479.40 In stock
Bulk Quote

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Description

Fotemustine is a chloroethylnitrosourea that exhibits anticancer chemotherapeutic benefit. Fotemustine alkylates or induces cross-links in DNA, halting cell cycle progression at the G2/M phase and inhibiting DNA repair mechanisms. Fotemustine displays greater cytotoxicity in methyl excision repair-deficient cells, indicating its primary site of alkylation is the O6 site of guanine bases. Fotemustine may also deactivate thioredoxin reductase, glutathione reductase, and ribonucleotide reductase by alkylating their thiol active sites.

Product Info

Cas No.

92118-27-9
Purity

≥98%
Formula

C9H19ClN3O5P
Formula Wt.

315.69
Chemical Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
IUPAC Name

1-(2-chloroethyl)-3-(1-diethoxyphosphorylethyl)-1-nitrosourea
Synonym

Mustophorane; Muphoran
Appearance

Light yellow

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

F5976 MSDS PDF
Info Sheet

F5976 Info Sheet PDF

References

Hayes MT, Bartley J, Parsons PG. In vitro evaluation of fotemustine as a potential agent for limb perfusion in melanoma. Melanoma Res. 1998 Feb;8(1):67-75. PMID: 9508380.

Hayes MT, Bartley J, Parsons PG, et al. Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity. Biochemistry. 1997 Sep 2;36(35):10646-54. PMID: 9271495.

Schallreuter KU, Gleason FK, Wood JM. The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. Biochim Biophys Acta. 1990 Aug 13;1054(1):14-20. PMID: 2200526.

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