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FRAX486

FRAX486

Product ID F6803
Cas No. 1232030-35-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $127.90 In stock
5 mg $217.90 In stock
10 mg $375.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

FRAX486 is an inhibitor of PAK that is currently under investigation as a potential treatment for schizophrenia; it exhibits neuroprotective activity and anti-psychotic potential. In vitro, FRAX486 ameliorates synaptic deterioration induced by DISC1 knockdown. In animal models of fragile X syndrome, FRAX486 rescues seizures and other behavioral abnormalities.

Product Info

Cas No.

1232030-35-1

Purity

≥98%

Formula

(C25H23Cl2FN6O)2 • H2O

Formula Wt.

522.40

IUPAC Name

6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one

Synonym

FRAX-486

Solubility

DMSO 22 mg/mL (42.85 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

F6803 MSDS PDF

Info Sheet

F6803 Info Sheet PDF

References

Hayashi-Takagi A, Araki Y, Nakamura M, et al. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6461-6. PMID: 24706880.

Dolan BM, Duron SG, Campbell DA, et al. Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6. PMID: 23509247.

Custom Order

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