Furosemide

Name: Furosemide
SKU: F8270
Availability: InStock

Product ID F8270

Cas No. 54-31-9

Purity ≥97%

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Description

Furosemide is a loop diuretic that is clinically used to treat congestive heart failure, edema, and hypertension; it inhibits the Na+/K+/Cl2- (NKCC) symporter and CFTR Cl- channels in the loop of Henle, decreasing reabsorption of Na+ and K+ and increasing secretion of Mg2+ and Ca2+. Furosemide exhibits antihypertensive, anxiolytic, and potentially antiepileptic/anticonvulsant activities. Furosemide noncompetitively inhibits GABA-A receptors and decreases conditioned anxiety in animal models of contextual fear conditioning and fear-potentiated startle.

Product Info

Cas No.	54-31-9
Purity	≥97%
Formula	C₁₂H₁₁ClN₂O₅S
Formula Wt.	330.74
Chemical Name	5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)- amino]benzoic acid
IUPAC Name	4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Synonym	Fursemide, Beronald, Discoid, Durafurid, Eutensin, Fulsix, Furosedon, Impugan, Katlex, Lasix, Macasirrol, Nicorol, Odemase, Rosemide, Urex
Melting Point	203-206°C
Solubility	Soluble in acetone, DMF, and methanol. Slightly soluble in water, chloroform and ether.
Appearance	Cream/ Off-White powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	F8270 MSDS PDF
Info Sheet	F8270 Info Sheet PDF

References

Ju M, Scott-Ward TS, Liu J, et al. Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics. Br J Pharmacol. 2014 Jan;171(1):265-78. PMID: 24117047.

Krystal AD, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012;7(4):e35417. PMID: 22514741.

Somasekharan S, Tanis J, Forbush B. Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1). J Biol Chem. 2012 May 18;287(21):17308-17. PMID: 22437837.

Korpi ER, Kuner T, Seeburg PH, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. PMID: 7870036.

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Furosemide

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