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Fusarenon X is a Fusarium type B trichothecene mycotoxin. In vitro, this compound displays significant genotoxic and cytotoxic activity, increasing DNA strand breaks. In vivo, fusarenon X induces an anorectic response resulting in food refusal. This mycotoxin was initially produced by mycoplasma in barley, maize, oats, and other livestock feed grains.
| Cas No. | 23255-69-8 |
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| Purity | ≥98% |
| Formula | C17H22O8 |
| Formula Wt. | 354.35 |
| Chemical Name | 12,13-epoxy-3 alpha,4 beta,7 beta,15-tetrahydroxytrichothec-9-en-8-one 4-acetate |
| IUPAC Name | [(1S,2R,3S,7R,9R,10R,11S,12S)-3,10-dihydroxy-2-(hydroxymethyl)-1,5-dimethyl-4-oxospiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-11-yl] acetate |
| Synonym | Nivalenol monoacetate, Nivalenol-4-o-acetate, 4-acetyl Nivalenol, NSC 197211, NSC197211, NSC-197211 |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.
Wu W, Flannery BM, Sugita-Konishi Y, et al. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem Toxicol. 2012 Jun;50(6):2056-61. PMID: 22465835.
Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.
Bony S, Olivier-Loiseau L, Carcelen M, et al. Genotoxic potential associated with low levels of the Fusarium mycotoxins nivalenol and fusarenon X in a human intestinal cell line. Toxicol In Vitro. 2007 Apr;21(3):457-65. PMID: 17161579.