Description
Gabapentin exhibits antiepileptic/anticonvulsant, sedative, analgesic, and antinociceptive activities. Gabapentin is a GABA analog that does not bind GABA receptors. Gabapentin binds the α2δ subunit of voltage-gated Ca2+ channels, decreasing Ca2+ currents and inhibiting Ca2+ signaling; gabapentin also activates adenosine A1 receptors, binds NMDA receptors, and potentiates the effects of GABA signaling. Gabapentin is clinically used to prevent seizures and to treat neuropathic, inflammatory, and cancer-related pain.