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Galanin, human

Galanin, human

Product ID G0146
Cas No. 119418-04-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $340.70 In stock
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Quicklinks

  • Description
  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Galanin is an endogenous neuropeptide that binds GAL receptors and is involved in action potential signaling and propagation in neurons. Galanin exhibits anticonvulsant/antiepileptic activity, inhibiting glutamate and suppressing seizures. Galanin also inhibits insulin secretion and plays a role in nociception, sleep regulation, cognition, feeding, blood pressure, and mood. Galanin displays both neuroprotective and neurotoxic activities, as galanin expression is increased in the brain tissue of Alzheimer’s disease patients; it is also involved in modulation of cholinergic signaling.

Product Info

Cas No.

119418-04-1

Purity

≥98%

Formula

C139H210N42O43

Formula Wt.

3157.44

Solubility

Soluble in 5% acetic acid.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G0146 MSDS PDF

Info Sheet

G0146 Info Sheet PDF

References

Mitsukawa K, Lu X, Bartfai T. Galanin, galanin receptors and drug targets. Cell Mol Life Sci. 2008 Jun;65(12):1796-805. PMID: 18500647.

Counts SE, Perez SE, Mufson EJ. Galanin in Alzheimer's disease: neuroinhibitory or neuroprotective? Cell Mol Life Sci. 2008 Jun;65(12):1842-53. PMID: 18500641.

Lang R, Gundlach AL, Kofler B. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther. 2007 Aug;115(2):177-207. PMID: 17604107.

Mazarati A, Lu X, Shinmei S, et al. Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience. 2004;128(2):431-41. PMID: 15350653.

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