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Galantamine Hydrobromide

Galantamine Hydrobromide

Product ID G0246
Cas No. 1953-04-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $61.10 In stock
25 mg $122.70 In stock
100 mg $204.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Galantamine is an alkaloid originally found in species of Galanthus, Narcissus, Leucojum, and Lycoris; it exhibits neuroprotective and cognition enhancing activities. Galantamine inhibits acetylcholinesterase (AChE) and acts as an allosteric agonist on nicotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mAChRs); it is somewhat selective for α7 nAChRs. Galantamine is clinically used to improve cognitive deficits in subjects with Alzheimer’s disease. Galantamine is neuroprotective and promotes neurogenesis in an IGF-2-dependent manner. Galantamine may also inhibit P2X7 receptors, increasing Bcl-2 expression and inhibiting apoptosis.

Product Info

Cas No.

1953-04-4

Purity

≥98%

Formula

C17H21NO3 • HBr

Formula Wt.

368.27

Chemical Name

(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy- 11-methyl-6H-benzofuronyl

IUPAC Name

(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide

Synonym

Nivalin, Galanthamine Hydrobromide

Melting Point

246-247°C (dec.)

Solubility

Soluble in water.

Appearance

A White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G0246 MSDS PDF

Info Sheet

G0246 Info Sheet PDF

References

Kita Y, Ago Y, Higashino K, et al. Galantamine promotes adult hippocampal neurogenesis via M1 muscarinic and α7 nicotinic receptors in mice. Int J Neuropsychopharmacol. 2014 Dec;17(12):1957-68. PMID: 24818616.

Tsvetkova D, Obreshkova D, Zheleva-Dimitrova D, et al. Antioxidant activity of galantamine and some of its derivatives. Curr Med Chem. 2013;20(36):4595-608. PMID: 23834167.

Ago Y, Koda K, Takuma K, et al. Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. J Pharmacol Sci. 2011;116(1):6-17. PMID: 21498956.

Woodruff-Pak DS, Vogel RW 3rd, Wenk GL. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2089-94. PMID: 11172080.

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