Description
Gastrin I, like gastrin, acts as an agonist at the cholestocystokinin 2 (CCK2) receptor, exhibiting anorexigenic and gastrointestinal motility modulating activities. Gastrin is an endogenous peptide that inhibits food intake and slows gastric emptying, constricting the pyloric sphincter in vivo. Additionally, gastrin increases release of histamine and induces membrane translocation of the H+/K+ ATPase, stimulating gastric acid release. Expression of this particular fragment of gastrin (18-34) may correlate with the occurrence of tumor tissues in some cancers.