Description
GDC-0152 is an X-linked inhibitor of apoptosis protein (XIAP). GDC-0152 induces apoptosis in several cell lines including HL-60, NB4, osteosarcoma, glioblastomas among others.
GDC-0152 Free Base
Product ID G124086
Cas No. 873652-48-3
Purity ≥96%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 873652-48-3 |
|---|---|
| Purity | ≥96% |
| Formula | C25H34N6O3S |
| Formula Wt. | 498.65 |
| Chemical Name | N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-L-prolinamide |
| IUPAC Name | N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-L-prolinamide |
| Synonym | GDC0152, GDC 0152 |
| Solubility | DMSO |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Liang, P, Hu, R, Dong, HM, et al. GDC-0152-induced autophagy promotes apoptosis in HL-60 cells. Mol Cell Biochem 445:135-143 (2018). PMID:29299747 DOI:10.1007/s11010-017-3258-7.
Yang, L, Shu T, Liang, Y, et al GDC-0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2bia PI3K/AKT but not p38MAPK signaling pathway. Int J Oncol. 46:1651-8 (2015). PMID:25651778.
Shekhar, TM, Burvenich, IJG, HARRIS, M., ET AL SMAC MIMETICS LCL161 AND GDC-0152 INHIBIT OSTEOSARCOMA GROWTH AND METASTAsis IN MICE. BMC Cancer 19:924 (2019). PMID:31521127
Dizdar, L, Junemann LM, Werner TA., et al. Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer Oncol Lett 15:3779-3789 (2018) PMID: 2946 7895