Geranylgeraniol

Name: Geranylgeraniol
SKU: G1869
Availability: InStock

Product ID G1869

Cas No. 24034-73-9

Purity ≥85%

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Description

Geranylgeraniol is a diterpene alcohol that is a cell permeable analog of geranylgeranyl pyrophosphate; it is used in the biosynthesis of vitamin E, vitamin K, and other diterpenes. Geranylgeraniol is a bee pheromone and a substrate for geranylgeranyl transferase. This compound exhibits anticancer, antibacterial, and cytoprotective activities. Geranylgeraniol induces apoptosis and inhibits growth of various tumor cells. Separately, geranylgeraniol inhibits growth of Mycobacterium in vitro and protects monocytes against statin-induced cytotoxicity.

Product Info

Cas No.	24034-73-9
Purity	≥85%
Formula	C₂₀H₃₄O
Formula Wt.	290.49
Chemical Name	3,7,11,15-Tetramethyl-2,6,10,14-hexadecatraen-1-ol
IUPAC Name	(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol
Synonym	all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen- 1-ol
Solubility	Soluble in chloroform, alcohols, acetone, or ethyl acetate.
Appearance	Light Yellow Oil

Shipping and Storage

Store Temp	-20°C
Ship Temp	Blue Ice

Downloads

MSDS	G1869 MSDS PDF
Info Sheet	G1869 Info Sheet PDF

References

Campia I, Lussiana C, Pescarmona G, et al. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. Br J Pharmacol. 2009 Dec;158(7):1777-86. PMID: 19888963.

Vik A, James A, Gundersen LL. Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro. Planta Med. 2007 Oct;73(13):1410-2. PMID: 17924309.

Shibayama-Imazu T, Sakairi S, Watanabe A, et al. Vitamin K(2) selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol. J Cancer Res Clin Oncol. 2003 Jan;129(1):1-11. PMID: 12618894.

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Geranylgeraniol

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