LKT Labs

Biochemicals for Life Science Research

Gestrinone

Gestrinone

Product ID G1975
Cas No. 16320-04-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 Please Inquire
100 mg $194.00 Please Inquire
500 mg $817.00 In stock
Bulk Quote

Quicklinks

Description

Gestrinone is a synthetic anti-progestin hormone that acts as an antagonist at estrogen and progesterone receptors and as an agonist at androgen receptors. Gestrinone is primarily used to treat endometriosis in clinical settings; it is also in clinical trials for potential use as an emergency contraceptive. This compound also exhibits some potential anticancer activity as well, downregulating expression of the progesterone receptor, estrogen receptor, and p-Src, inhibiting growth of uterine leiomyoma cells.

Product Info

Cas No.

16320-04-0
Purity

≥98%
Formula

C21H24O2
Formula Wt.

308.41
Chemical Name

(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
IUPAC Name

(8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15, 16-octahydrocyclopenta[a]phenanthren-3-one
Synonym

13b-ethyl-17a-ethynyl-17b-hydroxy-4,9,11-gonatrien-3-one, 13b-ethyl-17a-ethynyl-D4,9,11-gonatriene-17b-ol-3-one, ethylnorgestrienone
Melting Point

154°C
Appearance

Yellowish crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

G1975 MSDS PDF
Info Sheet

G1975 Info Sheet PDF

References

Zhu Y, Zhang T, Xie S, et al. Gestrinone inhibits growth of human uterine leiomyoma may relate to activity regulation of ERα, Src and P38 MAPK. Biomed Pharmacother. 2012 Dec;66(8):569-77. PMID: 23102719.

Wu S, Dong J, Cong J, et al. Gestrinone compared with mifepristone for emergency contraception: a randomized controlled trial. Obstet Gynecol. 2010 Apr;115(4):740-4. PMID: 20308833.

Ohno Y, Kitagawa I, Tamura H, et al. Antiestrogenic effect of gestrinone as an inhibitor of [3H]-estradiol binding to nuclear type II sites. Gynecol Obstet Invest. 1991;31(2):97-101. PMID: 2037266.

Venturini PL, Bertolini S, Brunenghi MC, et al. Endocrine, metabolic, and clinical effects of gestrinone in women with endometriosis. Fertil Steril. 1989 Oct;52(4):589-95. PMID: 2806598.

Tamaya T, Fujimoto J, Watanabe Y, et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65(5):439-41. PMID: 3490730.

Kauppila A, Isomaa V, Rönnberg L, et al. Effect of gestrinone in endometriosis tissue and endometrium. Fertil Steril. 1985 Oct;44(4):466-70. PMID: 2996949.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M578522

    Monascin

    Fungal pigment found in red yeast rice

    ≥98%
  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%
  • M184776

    5-(Methylsulfonyl)pentyl Nitrile

    Synthetic nitrile compound

    ≥98%
  • O0830

    Ochratoxin B

    Non-chlorinated analogue of the mycotoxin Ochra...

    ≥99%
  • T0104

    Taxol Side Chain Methyl Ester

    Side chain attached to various taxanes.

    ≥96%
  • H9862

    Hypothemycin

    Polyketide found in Setophoma.

    ≥96%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • H1992

    Hexaconazole

    Triazole; demethylation inhibitor.

    ≥95%
  • T0096

    Cephalomannine

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • X0254

    Xanthohumol

    Prenylated flavonoid found in Humulus lupulus.<...

    ≥98%
  • I6933

    Irinotecan Hydrochloride Trihydrate

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • Z1970

    Zerumbone

    Cyclic sesquiterpene found in ginger root; pote...

    ≥99%
  • F130280

    FHD-286

    BRG1/BRM ATPase inhibitor

    ≥98%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • G0044

    Galantide

    Peptide; galanin antagonist.

    ≥95%
  • M4004

    MK-2461

    MET, FGFR, PDGFR inhibitor.

    ≥99%
  • L5822

    Lofexidine Hydrochloride

    α2-adrenergic agonist.

    ≥98%
  • C9882

    Cytochalasin E

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • E8419

    Everolimus

    mTORC1 inhibitor.

    ≥98%
  • S8012

    [Sar9]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%