Gestrinone

Name: Gestrinone
SKU: G1975
Availability: InStock

Product ID G1975

Cas No. 16320-04-0

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Gestrinone is a synthetic anti-progestin hormone that acts as an antagonist at estrogen and progesterone receptors and as an agonist at androgen receptors. Gestrinone is primarily used to treat endometriosis in clinical settings; it is also in clinical trials for potential use as an emergency contraceptive. This compound also exhibits some potential anticancer activity as well, downregulating expression of the progesterone receptor, estrogen receptor, and p-Src, inhibiting growth of uterine leiomyoma cells.

Product Info

Cas No.	16320-04-0
Purity	≥98%
Formula	C₂₁H₂₄O₂
Formula Wt.	308.41
Chemical Name	(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
IUPAC Name	(8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15, 16-octahydrocyclopenta[a]phenanthren-3-one
Synonym	13b-ethyl-17a-ethynyl-17b-hydroxy-4,9,11-gonatrien-3-one, 13b-ethyl-17a-ethynyl-D4,9,11-gonatriene-17b-ol-3-one, ethylnorgestrienone
Melting Point	154°C
Appearance	Yellowish crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	G1975 MSDS PDF
Info Sheet	G1975 Info Sheet PDF

References

Zhu Y, Zhang T, Xie S, et al. Gestrinone inhibits growth of human uterine leiomyoma may relate to activity regulation of ERα, Src and P38 MAPK. Biomed Pharmacother. 2012 Dec;66(8):569-77. PMID: 23102719.

Wu S, Dong J, Cong J, et al. Gestrinone compared with mifepristone for emergency contraception: a randomized controlled trial. Obstet Gynecol. 2010 Apr;115(4):740-4. PMID: 20308833.

Ohno Y, Kitagawa I, Tamura H, et al. Antiestrogenic effect of gestrinone as an inhibitor of [3H]-estradiol binding to nuclear type II sites. Gynecol Obstet Invest. 1991;31(2):97-101. PMID: 2037266.

Venturini PL, Bertolini S, Brunenghi MC, et al. Endocrine, metabolic, and clinical effects of gestrinone in women with endometriosis. Fertil Steril. 1989 Oct;52(4):589-95. PMID: 2806598.

Tamaya T, Fujimoto J, Watanabe Y, et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65(5):439-41. PMID: 3490730.

Kauppila A, Isomaa V, Rönnberg L, et al. Effect of gestrinone in endometriosis tissue and endometrium. Fertil Steril. 1985 Oct;44(4):466-70. PMID: 2996949.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Gestrinone

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

GDC-0032

Hyperforin Dicyclohexylammonium

n-Octyl-4-methylcaffeate

Puupehenone

Palmitoyl-L-carnitine

Sulfluramid

Altertoxin 1

Emtricitabine

Ketotifen Fumarate

Corosolic Acid

Sertraline Hydrochloride

Esomeprazole Magnesium Trihydrate

S-(−)-Schisandrin B

β-Endorphin, human

Plasminogen Activator Inhibitor 1

BAY80-6946

Manumycin A

BAY80-6946 Hydrochloride

IC-87114

Etidronate Disodium

Footer