LKT Labs

Biochemicals for Life Science Research

Gestrinone

Gestrinone

Product ID G1975
Cas No. 16320-04-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 Please Inquire
100 mg $194.00 Please Inquire
500 mg $817.00 In stock
Bulk Quote

Quicklinks

Description

Gestrinone is a synthetic anti-progestin hormone that acts as an antagonist at estrogen and progesterone receptors and as an agonist at androgen receptors. Gestrinone is primarily used to treat endometriosis in clinical settings; it is also in clinical trials for potential use as an emergency contraceptive. This compound also exhibits some potential anticancer activity as well, downregulating expression of the progesterone receptor, estrogen receptor, and p-Src, inhibiting growth of uterine leiomyoma cells.

Product Info

Cas No.

16320-04-0
Purity

≥98%
Formula

C21H24O2
Formula Wt.

308.41
Chemical Name

(17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
IUPAC Name

(8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,14,15, 16-octahydrocyclopenta[a]phenanthren-3-one
Synonym

13b-ethyl-17a-ethynyl-17b-hydroxy-4,9,11-gonatrien-3-one, 13b-ethyl-17a-ethynyl-D4,9,11-gonatriene-17b-ol-3-one, ethylnorgestrienone
Melting Point

154°C
Appearance

Yellowish crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

G1975 MSDS PDF
Info Sheet

G1975 Info Sheet PDF

References

Zhu Y, Zhang T, Xie S, et al. Gestrinone inhibits growth of human uterine leiomyoma may relate to activity regulation of ERα, Src and P38 MAPK. Biomed Pharmacother. 2012 Dec;66(8):569-77. PMID: 23102719.

Wu S, Dong J, Cong J, et al. Gestrinone compared with mifepristone for emergency contraception: a randomized controlled trial. Obstet Gynecol. 2010 Apr;115(4):740-4. PMID: 20308833.

Ohno Y, Kitagawa I, Tamura H, et al. Antiestrogenic effect of gestrinone as an inhibitor of [3H]-estradiol binding to nuclear type II sites. Gynecol Obstet Invest. 1991;31(2):97-101. PMID: 2037266.

Venturini PL, Bertolini S, Brunenghi MC, et al. Endocrine, metabolic, and clinical effects of gestrinone in women with endometriosis. Fertil Steril. 1989 Oct;52(4):589-95. PMID: 2806598.

Tamaya T, Fujimoto J, Watanabe Y, et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65(5):439-41. PMID: 3490730.

Kauppila A, Isomaa V, Rönnberg L, et al. Effect of gestrinone in endometriosis tissue and endometrium. Fertil Steril. 1985 Oct;44(4):466-70. PMID: 2996949.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S6233

    Spiramycin Hexanedioate

    Macrolide; protein synthesis inhibitor.

    ≥90%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • G7340

    GSK-126

    EZH2 HMT inhibitor.

    ≥98%, ≥99%ee
  • L1761

    Leptomycin B

    Polyketide; CRM1 inhibitor.

    ≥98%
  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • P2410

    Phenethyl Dimethyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • H9615

    17α-Hydroxyprogesterone Caproate

    Synthetic steroid hormone; ER antagonist.

    ≥98%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • T1674

    Terbutaline Sulfate

    β2-adrenergic agonist, potential ENaC activato...

    ≥98%
  • J889290

    JWH 133

    Cannabinoid receptor 2 selective agonist.

    ≥95%
  • J766160

    JTE907

    Selective Cannabinoid receptor 2(CB2) inverse a...

    ≥98%
  • G4799

    Glycitin

    Glycosylated isoflavone found in soy; TAS2R ago...

    ≥98%
  • P0144

    Paliperidone

    D2 and 5-HT2A antagonist.

    ≥97%
  • M1676

    Methotrexate Hydrate

    DHF reductase inhibitor.

    ≥98%
  • C9773

    L-Cystine

    Endogenous amino acid, forms disulfide bridges ...

    ≥98%
  • A1096

    Acyclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • T342710

    Tirzepatide

    GLP-1/GIP receptor co-agonist

    ≥98%
  • T9969

    Tyrphostin AG490

    JAK2 inhibitor, potential EGFR inhibitor.

    ≥98%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • G1721

    Gefitinib

    EGFR inhibitor.

    ≥98%