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GNF-5

GNF-5

Product ID G5322
Cas No. 778277-15-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $99.80 In stock
100 mg $278.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GNF-5 is an inhibitor of Abl that decreases cytokinesis in vitro and displays anti-diabetic, anti-inflammatory, and anti-asthma activities. In vivo, GNF-5 prevents streptozocin-induced loss of pancreatic β-cells and normalizes blood glucose levels. GNF-5 also inhibits OVA-induced increases in IL-13 and CCL2 levels as well as airway resistance in vivo.

Product Info

Cas No.

778277-15-9

Purity

≥99%

Formula

C20H17F3N4O3

Formula Wt.

418.38

IUPAC Name

N-(2-Hydroxyethyl)-3-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide

Solubility

DMSO 83 mg/mL (198.38 mM) Ethanol 20 mg/mL warmed (47.8 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G5322 MSDS PDF

Info Sheet

G5322 Info Sheet PDF

References

Karunakaran U, Park SJ, Jun do Y, et al. Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis. Cell Signal. 2015 Jun;27(6):1066-74. PMID: 25683919.

Chen S, Tang DD. c-Abl tyrosine kinase regulates cytokinesis of human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1076-83. PMID: 24392933.

Cleary RA, Wang R, Wang T, et al. Role of Abl in airway hyperresponsiveness and airway remodeling. Respir Res. 2013 Oct 11;14:105. PMID: 24112389.

Custom Order

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