Goserelin Acetate

Name: Goserelin Acetate
SKU: G5772
Availability: InStock

Product ID G5772

Cas No. 145781-92-6

Purity ≥95%

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Product Info
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References

Description

Goserelin acts as a peptide agonist at the gonadotropin-releasing hormone (GnRH) or luteinizing hormone releasing hormone (LHRH) receptor, stimulating release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and decreasing androgen levels. Goserelin exhibits anticancer chemotherapeutic benefit, inhibiting cell proliferation and tumor growth in cellular and animal models of prostate cancer, likely through indirect activation of PKC and inhibition of EGFR activity. Goserelin also inhibits cell proliferation and tumor growth in cellular and animal models of ovarian cancer through a mechanism that involves inhibition of Akt phosphorylation. In other animal models, goserelin increases bone elongation.

Product Info

Cas No.	145781-92-6
Purity	≥95%
Formula	C₅₉H₈₄N₁₈O₁₄ C₂H₄O₂
Formula Wt.	1329.48
IUPAC Name	acetic acid;N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Solubility	Soluble in water (20 mg/mL), DMSO.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G5772 MSDS PDF
Info Sheet	G5772 Info Sheet PDF
Brochures	PI3K-Akt-mTORC Pathway Booklet

References

Detti L, Uhlmann RA, Zhang J, et al. Goserelin fosters bone elongation but does not prevent ovarian damage in cyclophosphamide-treated prepubertal mice. Fertil Steril. 2014 Jan 23. pii: S0015-0282(13)03460-2. [Epub ahead of print]. PMID: 24462062.

Zhang Y, Ding JX, Tao X, et al. Goserelin can inhibit ovarian cancer proliferation and simultaneously protect ovarian function from cisplatin: an in vitro and in vivo study. J Chemother. 2013 Apr;25(2):96-103. PMID: 23684357.

Wells A, Souto JC, Solava J, et al. Luteinizing hormone-releasing hormone agonist limits DU-145 prostate cancer growth by attenuating epidermal growth factor receptor signaling. Clin Cancer Res. 2002 Apr;8(4):1251-7. PMID: 11948140.