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GS-4997

GS-4997

Product ID G720004
Cas No. 1448428-04-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $71.70 In stock
25 mg $220.50 In stock
100 mg $799.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GS-4997 is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1). ASK1 is an important mediator of oxidative stress effects. It has shown efficacy in the treatment of cancer cell lines exhibiting overexpression of ABC transporters. It is also being evaluated as a treatment for non-alcoholic steatohepatitis (NASH).

Product Info

Cas No.

1448428-04-3

Purity

≥99%

Formula

C24H24FN7O

Formula Wt.

445.5

IUPAC Name

5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-[6-(4-isopropyl-4H-1,2,4-triazol-3-yl)-2-pyridinyl]-4-methylbenzamide

Synonym

GS 4997, GS4997, Selonsertib

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G720004 MSDS PDF

Info Sheet

G720004 Info Sheet PDF

References

Ji N., Yang Y., et al. Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. Cancer Lett. 440-441:82-93 (2019). PMID: 30315846.

Mukherjee S., Zhelnin L., et al. Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype. Am J Transl Res. 11(3):1531-40 (2019). PMID: 30972180.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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