Description
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Cas No. | 1640247-87-5 |
|---|---|
| Purity | ≥99% |
| Formula | C22H17ClFN9O |
| Formula Wt. | 477.89 |
| IUPAC Name | 2,4-Diamino-6-({[5-chloro-8-fluoro-4-oxo-3-(3-pyridinyl)-3,4-dihydro-2-quinazolinyl](cyclopropyl)methyl}amino)-5-pyrimidinecarbonitrile |
| Synonym | GS 9901, GS9901 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel L., Chandrasekhar J., et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 59(19):9928-42 (2016). PMID:27660855.
DPP4 inhibitor.
Vitamin B1
Endogenous neuropeptide hormone; somatostatin a...
Voltage-gated Na+, Ca2+, K+ channel blocker, α...
Fumaric acid methyl ester; nAChR agonist, indir...
Found in plants in Astragalus, Allium, and Bras...
BRD2/3/4 inhibitor.
Quaternary base alkaloid found in Phellodendron...
Polyphenolic compound present in black tea.
5-HT3 antagonist.
Terpene found in the rind of various citrus fru...
Fluoroquinolone; topoisomerase IV, topoisomeras...
14-α demethylase inhibitor.
Peptide fragment
pan-PI3K inhibitor
AT1 antagonist.
Peptide, oxytocin-vasopressin analog.
MET, VEGFR2, Ron, Axl, FLT3 inhibitor.
Shellfish toxin produced by dinoflagellates and...
Statin, naturally produced by mushrooms; HMG-Co...