Description
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Cas No. | 1640247-87-5 |
|---|---|
| Purity | ≥99% |
| Formula | C22H17ClFN9O |
| Formula Wt. | 477.89 |
| IUPAC Name | 2,4-Diamino-6-({[5-chloro-8-fluoro-4-oxo-3-(3-pyridinyl)-3,4-dihydro-2-quinazolinyl](cyclopropyl)methyl}amino)-5-pyrimidinecarbonitrile |
| Synonym | GS 9901, GS9901 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel L., Chandrasekhar J., et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 59(19):9928-42 (2016). PMID:27660855.
Bactericidal
Selective inhibitor of c-Met.
Terpene found in the rind of various citrus fru...
Vitamin B6 derivative, antioxidant.
Labdane diterpene found in Andrographis; RLR (R...
5-HT1A partial agonist, SERT inhibitor.
All-trans nonaprenol isoprenoid, found in Solan...
Side chain attached to various taxanes.
NSAID; COX-1/2 inhibitor.
ET-A/B antagonist.
Steroid; AR antagonist.
PDE and adenosine deaminase inhibitor.
α1-adrenergic antagonist.
PKA inhibitor.
Protease substrate.
Carbonic anhydrase inhibitor.
Third generation macrocyclic ALK inhibitor.
Thiazolidinone macrolide found in the Red Sea s...
Basic phenol skeleton structure found in variou...
TNKS1/2 inhibitor.