Description
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Cas No. | 1640247-87-5 |
|---|---|
| Purity | ≥99% |
| Formula | C22H17ClFN9O |
| Formula Wt. | 477.89 |
| IUPAC Name | 2,4-Diamino-6-({[5-chloro-8-fluoro-4-oxo-3-(3-pyridinyl)-3,4-dihydro-2-quinazolinyl](cyclopropyl)methyl}amino)-5-pyrimidinecarbonitrile |
| Synonym | GS 9901, GS9901 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel L., Chandrasekhar J., et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 59(19):9928-42 (2016). PMID:27660855.
Diamidine; ACE2 activator, DNA polymerase inhib...
PARP1/2 inhibitor.
Alkylphospholipid analog; Akt inhibitor.
Thio sulforaphane analog, ITC.
Antimicrobial peptide found in bee and wasp ven...
SERM, androgen modulator.
mAChR antagonist.
Diterpene lactone found in Ginkgo; GABA-A, α-1...
Glutathione-S-transferase inhibitor.
Triterpenoid
Light-emitting luciferin analog found in aquati...
Atazanavir metabolite; HIV protease inhibitor.<...
ROCK1/2 inhibitor, potential RSK and p70S6K inh...
Triterpene saponin found in Bupleurum.
Shellfish toxin produced by dinoflagellates and...
Taxane found in species of Taxus; potential mic...
SIRT inhibitor.
Nucleoside (deoxyadenosine) analog; DNA chain t...
PLK1 inhibitor.