Description
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Cas No. | 1640247-87-5 |
|---|---|
| Purity | ≥99% |
| Formula | C22H17ClFN9O |
| Formula Wt. | 477.89 |
| IUPAC Name | 2,4-Diamino-6-({[5-chloro-8-fluoro-4-oxo-3-(3-pyridinyl)-3,4-dihydro-2-quinazolinyl](cyclopropyl)methyl}amino)-5-pyrimidinecarbonitrile |
| Synonym | GS 9901, GS9901 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel L., Chandrasekhar J., et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 59(19):9928-42 (2016). PMID:27660855.
Thienopyridine; P2Y12 antagonist.
FIASMA, μOR agonist, potential HCN channel blo...
Neuroactive mycotoxin produced by Penicillum an...
Calcineurin inhibitor, potential TRPV1 agonist....
Chaetocin is naturally produced by Chaetomium s...
Endogenous purine derivative of xanthine.
Chloroethylnitrosourea, DNA alkylator and cross...
Mycotoxin produced by species of Aspergillus; D...
PI3K and PDK1 inhibitor.
USP1 inhibitor
LBQ657 prodrug; neprilysin inhibitor.
Natriuretic, vasodilatory peptide; B1/2 agonist...
Found in propolis; 5-lipoxygenase inhibitor.
Isoflavone, phytoestrogen found in soy; ER agon...
β-lactam cephalosporin; penicillin binding pro...
Endogenous opioid peptide; μOR agonist.
Reduces production of thyroid hormones
Tropane alkaloid found in Solanaceae plants; α...
Piroxicam prodrug, NSAID; COX-1/2 inhibitor.
Derivative of methyl caffeate, hydroxycinnamic ...