Description
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Product Unit Size | Cost | Quantity | Stock |
|---|
GS-9901 is a selective inhibitor of the delta isoform of PI3K (PI3Kδ). PI3Kδ is overexpressed in many hematological malignancies as well as rheumatoid arthritis.
| Cas No. | 1640247-87-5 |
|---|---|
| Purity | ≥99% |
| Formula | C22H17ClFN9O |
| Formula Wt. | 477.89 |
| IUPAC Name | 2,4-Diamino-6-({[5-chloro-8-fluoro-4-oxo-3-(3-pyridinyl)-3,4-dihydro-2-quinazolinyl](cyclopropyl)methyl}amino)-5-pyrimidinecarbonitrile |
| Synonym | GS 9901, GS9901 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel L., Chandrasekhar J., et al. Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability. J Med Chem. 59(19):9928-42 (2016). PMID:27660855.
Steroid; glucocorticoid agonist.
GABA-A agonist, NMDA antagonist, voltage-gated ...
Mycotoxin contaminant found in cereal grains.
PORCN inhibitor.
Triterpenoid
Enone.
Antioxidant; Nrf2 activator.
Endogenous sphingosine-based lipid, component o...
Nucleoside antibiotic mixture; GlcNAc phosphotr...
Cdc42 GTPase inhibitor.
NSAID; COX-1/2 inhibitor.
Endogenous peptide hormone, involved in secreti...
PDE3 inhibitor.
EGFR inhibitor.
Quinoline, food preservative; HSP90 inhibitor.<...
Peptide, used to tag proteins for affinity chro...
Shellfish toxin produced by dinoflagellates and...
Glucocorticoid
Natural steroid hormone produced by arthropods;...
Naturally sourced ITC, sulfonyl analog of sulfo...