Description
GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats.
Product Unit Size | Cost | Quantity | Stock |
---|
GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats.
Cas No. | 864082-47-3 |
---|---|
Purity | ≥98% |
Formula | C21H16F4N4O2 |
Formula Wt. | 432.37 |
Chemical Name | N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide |
IUPAC Name | N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide |
Synonym | GSK429286A |
Solubility | DMSO 87 mg/mL (201.21 mM) Ethanol 4 mg/mL (9.25 mM) Water Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Nichols RJ, Dzamko N, Hutti JE, et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60. PMID: 19740074.
Goodman KB, Cui H, Dowdell SE, et al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. PMID: 17201405.
CDK7 inhibitor
Organosulfur found in garlic; Kir K+ channel ac...
Benzyl taxol analog; potential microtubule depo...
JAK3 inhibitor.
Phenolic phytoalexin found in soy, grapes, and ...
SERT, NET, MAO inhibitor.
Endogenous cardiomodulatory peptide; NPR-A agon...
Non-depolarizing NMJ blocker; AChR antagonist.<...
ACE inhibitor.
β-lactamase inhibitor.
Endogenous sphingosine-based lipid, component o...
MEK1/2 inhibitor.
Neuraminidase inhibitor.
Flavone found in Scutellaria; prolyl oligopepti...
Nitroimidazole; DNA synthesis inhibitor.
Kavalactone originally found in Piper methystic...
Nucleoside (deoxyadenosine) analog; DNA chain t...
Endogenous adhesion molecule, binds PKC, calmod...
Mycotoxin that has structural similarity to est...
Nitrogen mustard and estradiol derivative; micr...