Helvolic acid

Name: Helvolic acid
SKU: H174466
Availability: InStock

Product ID H174466

Cas No. 29400-42-8

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Helvolic acid is a well-known fungal metabolite that inhibits protein synthesis through elongation factor G on the bacterial ribosome. It has shown in vitro antitrypanosomal activity against Trypanosoma brucei brucei GUTat3.1 with IC50 value of 5.08 µg/mL. Helvolic acid has also been found to be weakly cytotoxic against normal human diploid fibroblasts with IC50 value of >100 µg/mL. Furthermore, Helvolic acid has shown to exhibit strong antibacterial activities against two gram-positive bacteria: B. subtilis and methicillin-resistant Staphylococcus aureus.

Product Info

Cas No.	29400-42-8
Purity	≥98%
Formula	C₃₃H₄₄O₈
Formula Wt.	568.71
Chemical Name	(2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
IUPAC Name	(4α,5α,6β,8α,9β,13α,14β,16β,17E)-6,16-Diacetoxy-4,8,14-trimethyl-3,7-dioxo-18-norcholesta-1,17,24-trien-21-oic acid
Synonym	Fumigacin, NSC 319943, BRN 3230584
Solubility	Soluble in DMSO, acetone or chloroform. Insoluble in water.
Appearance	White to Off-White powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	H174466 MSDS PDF
Info Sheet	H174466 Info Sheet PDF

References

Ganaha M, Yoshii K, Otsuki Y, et al. In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683. Chem Pharm Bull (Tokyo). 2016;64(7):988-990. PMID: 27373660.

Jayanetti DR, Yue Q, Bills GF, et al. Hypocoprins A-C: new sesquiterpenoids from the coprophilous fungus Hypocopra rostrata. J Nat Prod. 2015 Mar 27;78(3):396-401. PMID: 25549014.

Ratnaweera PB, Williams DE, de Silva ED, et al. Helvolic acid, an antibacterial nortriterpenoid fmor the fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. PMID: 24772371.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Helvolic acid

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Neuromedin

EIDD-2801

Snake venom – Crotalus durissus terrificus

Cordycepin

Clindamycin Phosphate

PRI-724

Memantine Hydrochloride

Cafestol Eicosanate

TGX-221

GSK-126

I-BET-762

TMP-269

Alamethicin

Penicillin G procaine

Flavokawain A

Diclofenac Related Compound A

Pituitary Adenylate Cyclase-activating Polypeptide-related Peptide, human

Taxol Side Chain Methyl Ester

Hydrocortisone

5S rRNA modificator

Footer