• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Helvolic acid

Helvolic acid

Product ID H174466
Cas No. 29400-42-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $100.70 In stock
5 mg $450.80 In stock
10 mg $728.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Helvolic acid is a well-known fungal metabolite that inhibits protein synthesis through elongation factor G on the bacterial ribosome. It has shown in vitro antitrypanosomal activity against Trypanosoma brucei brucei GUTat3.1 with IC50 value of 5.08 µg/mL. Helvolic acid has also been found to be weakly cytotoxic against normal human diploid fibroblasts with IC50 value of >100 µg/mL. Furthermore, Helvolic acid has shown to exhibit strong antibacterial activities against two gram-positive bacteria: B. subtilis and methicillin-resistant Staphylococcus aureus.

 

Product Info

Cas No.

29400-42-8

Purity

≥98%

Formula

C33H44O8

Formula Wt.

568.71

Chemical Name

(2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

IUPAC Name

(4α,5α,6β,8α,9β,13α,14β,16β,17E)-6,16-Diacetoxy-4,8,14-trimethyl-3,7-dioxo-18-norcholesta-1,17,24-trien-21-oic acid

Synonym

Fumigacin, NSC 319943, BRN 3230584

Solubility

Soluble in DMSO, acetone or chloroform. Insoluble in water.

Appearance

White to Off-White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H174466 MSDS PDF

Info Sheet

H174466 Info Sheet PDF

References

Ganaha M, Yoshii K, Otsuki Y, et al. In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683. Chem Pharm Bull (Tokyo). 2016;64(7):988-990. PMID: 27373660.

Jayanetti DR, Yue Q, Bills GF, et al. Hypocoprins A-C: new sesquiterpenoids from the coprophilous fungus Hypocopra rostrata. J Nat Prod. 2015 Mar 27;78(3):396-401. PMID: 25549014.

Ratnaweera PB, Williams DE, de Silva ED, et al. Helvolic acid, an antibacterial nortriterpenoid fmor the fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. PMID: 24772371.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C2948

    Chloroadenosine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • S0134

    Saikosaponin D

    Triterpene saponin found in Bupleurum.

    ≥98%
  • A9600

    AZD-3463

    ALK and IGF-1R inhibitor.

    ≥99%
  • D582705

    Dorsomorphin Dihydrochloride

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • M7528

    α-Melanocyte Stimulating Hormone

    Endogenous peptide hormone derived from POMC, i...

    ≥98%
  • F1669

    Ferulic Acid

    Hydroxycinnamic acid found in various plant sou...

    ≥98%
  • P0255

    Pantoprazole

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%
  • O4549

    Olmesartan Medoxomil

    AT1 inhibitor.

    ≥98%
  • L0249

    Laminin Peptide YIGSR-NH2

    Laminin-derived peptapeptide.

    ≥98%
  • D0808

    DCC-2036

    Abl inhibitor.

    ≥98%
  • A5135

    Aminophylline Dihydrate

    Xanthine derivative; adenosine antagonist, PDE ...

    ≥98%
  • R4132

    RKI-1447

    ROCK1/2 inhibitor.

    ≥98%
  • D3430

    Dihydrosanguinarine

    Benzophenanthridine alkaloid, sanguinarine meta...

    ≥98%
  • E6814

    Erdosteine

    Thiol derivative, antioxidant.

    ≥98%
  • G0145

    Gallic Acid

    Phenol found in various plant sources, used to ...

    ≥98%
  • S1069

    Scriptaid

    HDAC inhibitor.

    ≥98%
  • A5272

    Angiotensin, dog/rat

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • S0501

    SB-939

    HDAC inhibitor.

    ≥98%
  • B807214

    Buflomedil Hydrochloride

    Alpha blocker and vasoactive agent.

    ≥99%
  • S8005

    Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only