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Herbimycin A

Product ID H1669
Cas No. 70563-58-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $489.50 Please Inquire
1 mg $1,158.30 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Herbimycin A is a benzoquinone ansamycin antibiotic that also exhibits anticancer activity. Herbimycin A inhibits HSP90, PKC, and some Src family kinases such as Src and Bcr-Abl. Herbimycin A inhibits cell proliferation in various in vitro cancer models, including chronic myelogenous leukemia (CML).

Product Info

Cas No.

70563-58-5

Purity

≥98%

Formula

C30H42N2O9

Formula Wt.

574.66

IUPAC Name

[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9, 15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12, 14,18-pentaen-10-yl] carbamate

Synonym

Herbimycin

Solubility

Soluble in DMSO.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

H1669 MSDS PDF

Info Sheet

H1669 Info Sheet PDF

References

Kasai S, Kikuchi H. The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. Biosci Biotechnol Biochem. 2010;74(1):36-43. PMID: 20057149.

Napolitano M, Bravo E. Activation of protein kinase C by phorbol esters in human macrophages reduces the metabolism of modified LDL by down-regulation of scavenger receptor activity. Int J Biochem Cell Biol. 2003 Jul;35(7):1127-43. PMID: 12672483.

Mucha DR, Myers CL, Schaeffer RC Jr. Endothelial contraction and monolayer hyperpermeability are regulated by Src kinase. Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H994-H1002. PMID: 12456392.

Ren H, Chen S, Lu D. Herbimycin A enhances apoptotic effect of chemotherapeutic drugs on K562 cells. Chin Med J (Engl). 1998 Aug;111(8):678-81. PMID: 11245017.

Fukazawa H, Li PM, Yamamoto C, et al. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochem Pharmacol. 1991 Oct 9;42(9):1661-71. PMID: 1656993.

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