LKT Labs

Biochemicals for Life Science Research

Hesperidin

Hesperidin

Product ID H1673
Cas No. 520-26-3
Purity ≥95%
Product Unit SizeCostQuantityStock
25 g $41.90 In stock
100 g $101.90 Please Inquire
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Description

Hesperidin is a phytoestrogen and flavonoid found in citrus plants that exhibits anti-hyperlipidemic, anti-osteoporotic, anti-inflammatory, analgesic, sedative, antinociceptive, and antioxidative activities. In vivo, hesperidin increases levels of HDL and decreases levels of LDL, triglycerides, and total lipids. In ovariectomized animals, hesperidin increases bone mineral density, preventing hormone-released changes in bone volume and thickness. Hesperidin also decreases carrageenan-induced edema and displays opioid-induced pain relief in various animal models. Additionally, hesperidin inhibits COX-2 activity and scavenges radicals.

Product Info

Cas No.

520-26-3
Purity

≥95%
Formula

C28H34O15
Formula Wt.

610.56
Chemical Name

(2S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D- glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3- hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
IUPAC Name

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[3,4,5-trihydroxy-6-[(3,4, 5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-2, 3-dihydrochromen-4-one
Synonym

Hesperetin 7-rhamnoglucoside, Cirantin, Hesperetin-7- rutinoside
Melting Point

258-262°C
Solubility

Insoluble in water. Soluble in DMF and DMSO (30 mg/mL). Slightly soluble in ethanol and methanol (~1 mg/mL).
Appearance

White to light tan powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

H1673 MSDS PDF
Info Sheet

H1673 Info Sheet PDF

References

Guzmán-Gutiérrez SL, Navarrete A. Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers. Planta Med. 2009 Mar;75(4):295-301. PMID: 19219759.

Loscalzo LM, Wasowski C, Paladini AC, et al. Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur J Pharmacol. 2008 Feb 12;580(3):306-13. PMID: 18048026.

Hirata A, Murakami Y, Shoji M, et al. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer Res. 2005 Sep-Oct;25(5):3367-74. PMID: 16101151.

Chiba H, Uehara M, Wu J, et al. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr. 2003 Jun;133(6):1892-7. PMID: 12771335.

Monforte MT, Trovato A, Kirjavainen S, et al. Biological effects of hesperidin, a Citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat. Farmaco. 1995 Sep;50(9):595-9. PMID: 7495469.

Emim JA, Oliveira AB, Lapa AJ. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol. 1994 Feb;46(2):118-22. PMID: 8021799.

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