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Honokiol

Honokiol

Product ID H5654
Cas No. 35354-74-6
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $81.20 In stock
25 mg $168.40 In stock
100 mg $561.40 In stock
Bulk Quote

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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Honokiol is a lignan originally found in species of Magnolia that exhibits anticancer chemotherapeutic, anti-angiogenic, antioxidative, neuroprotective, anti-inflammatory, antiviral, antithrombotic, and anxiolytic activities. Honokiol inhibits angiogenesis in epithelial cells and prevents tumor growth in animal models of angiosarcoma; it also suppresses growth and proliferation in oral squamous cell carcinoma cells. In animal models of cerebral ischemia/reperfusion, honokiol inhibits lipid peroxidation, ROS and inflammatory cytokine production, NF-κB activation, and neutrophil recruitment, infiltration, and adhesion. Honokiol also decreases platelet aggregation in vitro and increases time to thrombus formation in vivo. Additionally, this compound potentiates the effects of GABA-A receptors by acting at the benzodiazepine site and also inhibits cell entry and replication of hepatitis C virus and HIV-1. Honokiol also acts as an agonist at PPARγ receptors as wll as agonst at CB1 receptor and an antagonist at the CB2 receptor.

Product Info

Cas No.

35354-74-6

Purity

≥99%

Formula

C18H18O2

Formula Wt.

266.33

Chemical Name

3',5-Di-2-propenyl-[1,1'-biphenyl]-2,4'-diol

IUPAC Name

2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol

Synonym

5,3'-diallyl-2,4'-dihydroxydiphenyl

Melting Point

86-86.5°C

Solubility

Soluble in organic solvents and caustic alkali.DMSO to 53 mg/ml,

Appearance

Fine white to light yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

H5654 MSDS PDF

Info Sheet

H5654 Info Sheet PDF

References

Zhou Y, Tang J, Lan J, et al. Honokiol alleviated neurodegeneration by reducin oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis. Acta Pharm Sin B. 2023 Feb;13(2):577-597. PMID: 36873166.

Atanasov AG, Wang JN, Gu SP, et al. Honokiol: a non-adipogenic PPARγ agonist from nature. Biochim Biophys Acta. 2013 Oct;1830(10):4813-9. PMID: 23811337.

Zhang P, Liu X, Zhu Y, et al. Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells. Neurosci Lett. 2013 Feb 8;534:123-7. PMID: 23262090.

Lan KH, Wang YW, Lee WP, et al. Multiple effects of Honokiol on the life cycle of hepatitis C virus. Liver Int. 2012 Jul;32(6):989-97. PMID: 22098176.

Ku TH, Lee YJ, Wang SJ, et al. Effect of honokiol on activity of GAD(65) and GAD(67) in the cortex and hippocampus of mice. Phytomedicine. 2011 Oct 15;18(13):1126-9. PMID: 21561750.

Chen XR, Lu R, Dan HX, et al. Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells. Int J Oral Sci. 2011 Jan;3(1):34-42. PMID: 21449214

Hu H, Zhang XX, Wang YY, et al. Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin. Acta Pharmacol Sin. 2005 Sep;26(9):1063-8. PMID: 16115372.

Liou KT, Shen YC, Chen CF, et al. Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production. Brain Res. 2003 Dec 5;992(2):159-66. PMID: 14625055.

Bai X, Cerimele F, Ushio-Fukai M, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003 Sep 12;278(37):35501-7. PMID: 12816951.

Song JM, Anandharaj A, Upadhyaya P, et al. Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Oncotarget. 2016 Sep 6;7(36):57752-57769. PMID: 27458163.

Rempel V, Fuchs A, Hinz S, et al. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett. 2012, 4(1):41-5, PMID: 24900561 PMCID: PMC4027495 DOI: 10.1021/ml300235q

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