LKT Labs

Biochemicals for Life Science Research

Hydrolyzed Fumonisin B1

Hydrolyzed Fumonisin B1

Product ID H965142
Cas No. 145040-09-1
Purity ≥99% by ELSD
Product Unit SizeCostQuantityStock
100 µg $204.40 In stock
1 mg $1,567.20 Please Inquire
Bulk Quote

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Description

Hydrolyzed fumonisin B1 is a mycotoxin produced by Fusarium fungi that infect many cereal grains and other foods. Because of the high frequency and concentration of contamination, fumonisins are likely to have an impact on human and animal health. Fumonisins B1, B2, and B3 each have regulated limits set for corn in both the EU and US. Epidemiologic studies have associated fumonisins with the occurrance of human oesophageal cancer and neural tube defects. Hydrolyzed fumonisin B1 is a less toxic metabolite of fumonisin B1.

Product Info

Cas No.

145040-09-1
Purity

≥99% by ELSD
Formula

C22H47NO5
Formula Wt.

405.61
IUPAC Name

(2S,3S,5R,10R,12S,14S,15R,16R)-2-Amino-12,16-dimethyl-3,5,10,14,15-icosanepentol
Synonym

Aminopentol; AP1
Appearance

Yellow film

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H965142 MSDS PDF
Info Sheet

H965142 Info Sheet PDF

References

Masching S, Naehrer K, et al. Gastrointestinal degradation of fumonisin B1 by carboxylesterase FumD prevents fumonisin induced alteration of sphingolipid metabolism in turkey and swine. Toxins (Basel). 2016 Mar 21;8(3):pii:E84. PMID: 27007395.

Humpf HU, Schmelz EM, Meredith FI, et al. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category or ceramide synthase inhibitor. J Biol Chem. 1998 Jul 24;273(30):19060-19064. PMID: 9668088.

Matsuo Y, Takahara K, Sago Y, et al. Detection of N-(1-deoxy-D-fructos-1-yl) fumonisins B2 and B3 in corn by high-resolution LC-orbitrap MS. Toxins (Basel). 2015 Sep 16;7(9):3700-3714. PMID: 26389955.

Tamura M, Mochizuki N, Nagatomi Y, et al. A method for simultaneous determination of 20 Fusarium toxins in cereals by high-resolution liquid chromatography-orbitrap mass spectrometry with a pentafluorophenyl column. Toxins (Basel). 2015 May 14;7(5):1664-1682. PMID: 26008230.

Yoshinari T, Tanaka T, Ichikuro E, et al. Inter-laboratory study of LC-MS/MS method for simultaneous determination of fumonisin B1, B2 and B3 in corn. Shokuhin Eiseigaku Zasshi. 2013;54(4):266-276. PMID: 24025204.

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