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IC-87114

IC-87114

Product ID I0800
Cas No. 371242-69-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.60 In stock
5 mg $145.80 In stock
10 mg $264.40 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

IC-87114 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, anti-asthma, anti-angiogenic, and anti-diabetic activities. In animals, IC-87114 inhibits airway infiltration of lymphocytes, neutrophils, and eosinophils, decreases expression of IL-4, IL-5, IL-13, and IL-17, and prevents activation of NF-κB, improving airway hyperresponsiveness. In cellular models, IC-87114 impairs cardiac and vascular differentiation, inhibiting VEGF-induced phosphorylation of PKC, Akt, and PDK1. IC-87114 also decreases infiltration of inflammatory cells into pancreatic islets, suppressing loss of glucose homeostasis and preventing the progression of diabetes in animal models.

Product Info

Cas No.

371242-69-2

Purity

≥98%

Formula

C22H19N7O

Formula Wt.

397.43

IUPAC Name

2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one

Solubility

DMSO 0.66 mg/mL (1.66 mM) Water Insoluble Ethanol Insoluble

Appearance

White powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I0800 MSDS PDF

Info Sheet

I0800 Info Sheet PDF

References

Durand CA, Richer MJ, Brenker K, et al. Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice. Autoimmunity. 2013 Feb;46(1):62-73. PMID: 23039284.

Bekhite MM, Finkensieper A, Binas S, et al. VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1819-30. PMID: 21540297.

Park SJ, Lee KS, Kim SR, et al. Phosphoinositide 3-kinase δ inhibitor suppresses interleukin-17 expression in a murine asthma model. Eur Respir J. 2010 Dec;36(6):1448-59. PMID: 20351038.

Custom Order

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