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Imperatorin

Imperatorin

Product ID I4961
Cas No. 482-44-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $101.00 In stock
25 mg $404.30 In stock
100 mg $1,123.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Imperatorin is a furocoumarin that displays a wide variety of beneficial properties, including antihypertensive, vasodilatory, antioxidative, antibacterial, anti-parasitic, cognition enhancing, and neuroprotective activities. Imperatorin increases levels of catalase, xanthine oxidase, glutathione, NO, and NOS and decreases levels of angiotensin II in hypertensive rats. In vitro, imperatorin induces NO-regulated vasodilation in mouse thoracic aortic tissue. This compound is active against both gram positive and gram negative bacteria and also shows toxicity against Culex and Aedes mosquito larvae, indicating insecticide potential as well. In vitro, imperatorin inhibits caspase-3 and Bax expression and upregulates Bcl-2 and BDNF expression. In animal models of cerebral ischemia, imperatorin decreases infarct volume. Additionally, this compound inhibits voltage-gated Na+ channels in rat hippocampal neurons and displays inhibitory activity against both butyrlcholinesterase (BChE) and acetylcholinesterase (AChE). In animal models of Alzheimer’s disease, imperatorin improves memory acquisition and consolidation processes.

Product Info

Cas No.

482-44-0

Purity

≥98%

Formula

C16H14O4

Formula Wt.

270.28

Chemical Name

9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

IUPAC Name

9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

Synonym

Ammidin, Marmelosin, Pentosalen

Solubility

DMSO 10 mM. <0.3 mg/mL hot H2O.

Appearance

White Crystals

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I4961 MSDS PDF

Info Sheet

I4961 Info Sheet PDF

References

Granica S, Kiss AK, Jarończyk M, et al. Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors. Arch Pharm (Weinheim). 2013 Oct 14. [Epub ahead of print]. PMID: 24123207.

Wu KC, Chen YH, Cheng KS, et al. Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin. Eur J Pharmacol. 2013 Dec 5;721(1-3):49-55. PMID: 24113522.

Budzynska B, Boguszewska-Czubara A, Kruk-Slomka M, et al. Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice. Physiol Behav. 2013 Oct 2;122:46-55. PMID: 23999469.

Wang N, Wu L, Cao Y, et al. The protective activity of imperatorin in cultured neural cells exposed to hypoxia re-oxygenation injury via anti-apoptosis. Fitoterapia. 2013 Oct;90:38-43. PMID: 23856091.

Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.

Cao YJ, He X, Wang N, et al. Effects of imperatorin, the active component from Radix Angelicae (Baizhi), on the blood pressure and oxidative stress in 2K,1C hypertensive rats. Phytomedicine. 2013 Sep 15;20(12):1048-54. PMID: 23746952.

Wang Z, Kim JR, Wang M, et al. Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. Pest Manag Sci. 2012 Jul;68(7):1041-7. PMID: 22389164.

Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.

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