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Inauhzin

Inauhzin

Product ID I5203
Cas No. 309271-94-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $143.70 In stock
25 mg $582.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Inauhzin is an inhibitor of SIRT1 that activates p53; it also inhibits inosine monophosphate dehydrogenase (IMPDH). Inauhzin exhibits anticancer chemotherapeutic activities, inducing apoptosis and suppressing cell growth in non-small cell lung cancer (NSCLC) and colon cancer cells. This compound also induces senescence in and represses tumor growth in cellular and animal models of lung cancer and colon carcinoma.

Product Info

Cas No.

309271-94-1

Purity

≥98%

Formula

C25H19N5OS2

Formula Wt.

469.58

IUPAC Name

1-(10H-Phenothiazin-10-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-1-butanone

Synonym

INZ

Solubility

DMSO: 21 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I5203 MSDS PDF

Info Sheet

I5203 Info Sheet PDF

References

Zhang Q, Zhou X, Wu R, et al. The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. Elife. 2014 Oct 27;3. PMID: 25347121.

Zhang Y, Zhang Q, Zeng SX, et al. Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents. Neoplasia. 2013 May;15(5):523-34. PMID: 23633924.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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