LKT Labs

Biochemicals for Life Science Research

Indomethacin

Indomethacin

Product ID I5315
Cas No. 53-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $55.30 In stock
10 g $101.90 In stock
25 g $181.50 In stock
100 g $405.20 In stock
Bulk Quote

Quicklinks

Description

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, tocolytic, and anti-metastatic activities. Indomethacin is a non-selective COX-1 and COX-2 inhibitor that is clinically used to treat headaches; like other NSAIDs, indomethacin may induce intestinal damage or gastric lesions. Indomethacin delays premature labor in clinical settings by decreasing uterine contractility. In vitro, indomethacin decreases cancer cell migration by suppressing Ca2+ influx.

Product Info

Cas No.

53-86-1
Purity

≥98%
Formula

C19H16ClNO4
Formula Wt.

357.79
Chemical Name

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole- 3-acetic acid
IUPAC Name

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Synonym

Amuno, Idomethine.
Melting Point

158-162°C
Solubility

Insoluble in water. Soluble in ethanol (20 mg/mL), or acetone.
Appearance

White/Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I5315 MSDS PDF
Info Sheet

I5315 Info Sheet PDF

References

Adewoye EO, Salami AT. Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats. Niger J Physiol Sci. 2013 Dec 20;28(2):193-9. PMID: 24937396.

Guo YC, Chang CM, Hsu WL, et al. Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. Molecules. 2013 Jun 4;18(6):6584-96. PMID: 23736792.

Summ O, Evers S. Mechanism of action of indomethacin in indomethacin-responsive headaches. Curr Pain Headache Rep. 2013 Apr;17(4):327. PMID: 23423598.

Giles W, Bisits A. Preterm labour. The present and future of tocolysis. Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):857-68. PMID: 17459777.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G0048

    γ-Amino Butyric Acid

    Endogenous neurotransmitter; GABA agonist.

    ≥99%
  • T2935

    Thiamphenicol

    Chloramphenicol derivative; protein translation...

    ≥98%
  • A1017

    Aceclofenac

    Diclofenac analog, NSAID; COX-2 inhibitor.

    ≥98%
  • I525138

    Indoximod

    Indoleamine 2,3-dioxygenase inhibitor.

    ≥98%
  • O4578

    Oltipraz

    Antioxidant; Nrf2 activator.

    ≥98%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • O6805

    Orbifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥99%
  • T0205

    3”,4”-Dehydropaclitaxel C

    Semi-synthetic taxane.

    ≥95%
  • T1010

    7-Acetyl Paclitaxel

    Synthesis impurity

    ≥98%
  • E5178

    Emtricitabine

    Nucleoside (cytidine) analog; RT and telomerase...

    ≥98%
  • F6803

    FRAX486

    PAK inhibitor.Smo inhibitor.

    ≥98%
  • A3080

    AHU-377 Tris Salt

    LBQ657 prodrug; neprilysin inhibitor.

    ≥99%
  • P0092

    Paclitaxel, from Taxus yunnanensis

    Diterpene found in Taxus yunnanensis; microtubule ...
    ≥98%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%
  • SC7056

    Snake venom – Crotalus durissus terrificus

    Snake venom found in Crotalus durrisus terrific...

    ≥98%
  • C1600

    Carcinoembryonic Antigen (605-613)

    Carcinoembryonic antigen epitope.

    ≥95%
  • Z5744

    Zoledronic Acid Hydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • P200002

    PF-07321332

    Inhibitor of coronaviruses

    ≥99%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

    ≥98%