LKT Labs

Biochemicals for Life Science Research

Indomethacin

Product ID I5315
Cas No. 53-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $52.70 In stock
10 g $97.00 In stock
25 g $172.90 In stock
100 g $385.90 In stock
Bulk Quote

Quicklinks

Description

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, tocolytic, and anti-metastatic activities. Indomethacin is a non-selective COX-1 and COX-2 inhibitor that is clinically used to treat headaches; like other NSAIDs, indomethacin may induce intestinal damage or gastric lesions. Indomethacin delays premature labor in clinical settings by decreasing uterine contractility. In vitro, indomethacin decreases cancer cell migration by suppressing Ca2+ influx.

Product Info

Cas No.

53-86-1
Purity

≥98%
Formula

C19H16ClNO4
Formula Wt.

357.79
Chemical Name

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole- 3-acetic acid
IUPAC Name

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Synonym

Amuno, Idomethine.
Melting Point

158-162°C
Solubility

Insoluble in water. Soluble in ethanol (20 mg/mL), or acetone.
Appearance

White/Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I5315 MSDS PDF
Info Sheet

I5315 Info Sheet PDF

References

Adewoye EO, Salami AT. Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats. Niger J Physiol Sci. 2013 Dec 20;28(2):193-9. PMID: 24937396.

Guo YC, Chang CM, Hsu WL, et al. Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. Molecules. 2013 Jun 4;18(6):6584-96. PMID: 23736792.

Summ O, Evers S. Mechanism of action of indomethacin in indomethacin-responsive headaches. Curr Pain Headache Rep. 2013 Apr;17(4):327. PMID: 23423598.

Giles W, Bisits A. Preterm labour. The present and future of tocolysis. Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):857-68. PMID: 17459777.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G1646

    Geldanamycin

    HSP90 inhibitor.

    ≥97%
  • P2995

    Physcion

    Anthraquinone found in various plant sources.

    ≥96%
  • L3326

    Ligustrazine Hydrochloride

    Dihydropyrazine found in Ligusticum walliichi. ...

    ≥98%
  • H1662

    HER2/neu (654-662) GP2

    Peptide fragment of HER2/neu/erbB2 receptor.

    ≥95%
  • A7668

    Atracurium Besylate

    Non-depolarizing NMJ blocker; AChR antagonist.<...

    ≥95%
  • O6932

    Oridonin

    Diterpenoid found in Rabdosia rubescens; potent...

    ≥98%
  • G4634

    Glipizide

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • L0250

    Laminin Peptide SIKVAV

    Laminin-derived hexapeptide.

    ≥98%
  • M184776

    5-(Methylsulfonyl)pentyl Nitrile

    Synthetic nitrile compound

    ≥98%
  • S0224

    SAG

    Smoothened agonist.

    ≥98%
  • I5203

    Inauhzin

    p53 activator, IMPDH and SIRT1 inhibitor.

    ≥98%
  • D4802

    17-Dimethylaminoethylamino Demethoxygeldanamycin

    Geldanamycin derivative; HSP90 inhibitor.

    ≥98%
  • P7358

    Psoralen

    Furanocoumarin found in Psoralea coryfolia, DNA...

    ≥98%
  • R5602

    Ro 20-1724

    Phosphodiesterase inhibitor that produces anti-...

    ≥98%
  • S1058

    Scopolamine N-butylbromide

    Tropane alkaloid found in Solanaceae plants; M1...

    ≥98%
  • C0154

    7-Ethyl-10-hydroxycamptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • H9612

    Hydrocortisone 21-Acetate

    Steroid hormone involved in stress signaling; g...

    ≥98%
  • C3352

    Cinacalcet Hydrochloride

    Ca2+-sensing receptor agonist.

    ≥99%
  • C7692

    CTX IV (6-12)

    Snake venom cardiotoxin found in Naja naja atra...

    ≥98%