LKT Labs

Biochemicals for Life Science Research

Indomethacin

Indomethacin

Product ID I5315
Cas No. 53-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $55.30 In stock
10 g $101.90 In stock
25 g $181.50 In stock
100 g $405.20 In stock
Bulk Quote

Quicklinks

Description

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, tocolytic, and anti-metastatic activities. Indomethacin is a non-selective COX-1 and COX-2 inhibitor that is clinically used to treat headaches; like other NSAIDs, indomethacin may induce intestinal damage or gastric lesions. Indomethacin delays premature labor in clinical settings by decreasing uterine contractility. In vitro, indomethacin decreases cancer cell migration by suppressing Ca2+ influx.

Product Info

Cas No.

53-86-1
Purity

≥98%
Formula

C19H16ClNO4
Formula Wt.

357.79
Chemical Name

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole- 3-acetic acid
IUPAC Name

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Synonym

Amuno, Idomethine.
Melting Point

158-162°C
Solubility

Insoluble in water. Soluble in ethanol (20 mg/mL), or acetone.
Appearance

White/Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I5315 MSDS PDF
Info Sheet

I5315 Info Sheet PDF

References

Adewoye EO, Salami AT. Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats. Niger J Physiol Sci. 2013 Dec 20;28(2):193-9. PMID: 24937396.

Guo YC, Chang CM, Hsu WL, et al. Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. Molecules. 2013 Jun 4;18(6):6584-96. PMID: 23736792.

Summ O, Evers S. Mechanism of action of indomethacin in indomethacin-responsive headaches. Curr Pain Headache Rep. 2013 Apr;17(4):327. PMID: 23423598.

Giles W, Bisits A. Preterm labour. The present and future of tocolysis. Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):857-68. PMID: 17459777.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • U6802

    Urapidil Hydrochloride

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • T564091

    β-Tocopherol

    Vitamin E component

    ≥98%
  • D1628

    5,6-Dehydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • B6801

    Brassinin

    Phytoalexin, indole found in cruciferous vegeta...

    ≥98%
  • W5727

    Wogonoside

    Flavonoid glycoside found in Scutellaria.

    ≥98%
  • P200099

    PF-06939999

    PRMT5 inhibitor

    ≥98%
  • T0298

    Tazobactam

    β-lactamase inhibitor.

    ≥98%
  • A0958

    Aconitine

    Toxin found in Aconitum; voltage-gated Na+ chan...

    ≥95%
  • T0118

    7-epi-Cephalomannine

    Cephalomannine derivative found in Taxus; poten...

    ≥95%
  • P0013

    P7C3

    Aminopropyl carbazole, neuroprotective.

    ≥98%
  • D3214

    2′,3′-Dideoxyinosine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • H9816

    2-Hydroxyestradiol

    Estradiol metabolite.

    ≥99%
  • H9718

    2-Hydroxyflutamide

    Non-steroid; AR antagonist.

    ≥98%
  • T7036

    Triptorelin

    Peptide, GnRH analog; GnRH agonist.

    ≥98%
  • P7359

    Psoralidin

    Phenol found in Psoralea coryfolia.

    ≥98%
  • V1600

    VE-821

    ATR inhibitor.

    ≥98%
  • C4557

    Clofibrate

    Fibrate; PPARα agonist.

    ≥99%
  • G7240

    GSK-2830371

    Wip1 inhibitor.

    ≥98%
  • V344761

    Vitamin K2

    2-methyl-1,4-naphthoquinone derivative

    ≥98%
  • A0402

    Abacavir Sulfate

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%