• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
INK128

INK128

Product ID I5440
Cas No. 1224844-38-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $135.10 In stock
25 mg $390.70 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

INK-128 is an ATP-competitive inhibitor of mTOR, inhibiting both mTORC1 and mTORC2, protein complexes that modulate cell growth, cell survival, and cell migration. This compound displays anticancer chemotherapeutic and anti-metastatic activities in both in vitro and in vivo models. In vitro, INK-128 inhibits cell migration and adhesion, processes critical for the invasive nature of multiple myeloma; INK-128 also inhibits proliferation and decreases colony formation in an in vitro model of B-cell acute lymphoblastic leukemia. In vivo, INK-128 decreased metastases in an animal model of prostate cancer. This compound is currently in clinical trials as a potential treatment for multiple myeloma.

Product Info

Cas No.

1224844-38-5

Purity

≥99%

Formula

C15H15N7O

Formula Wt.

309.33

Chemical Name

5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1, 3-benzoxazol-2-amine

IUPAC Name

5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1, 3-benzoxazol-2-amine

Synonym

MLN-0128, Sapanisertib

Solubility

DMSO 62 mg/mL (200.43 mM) Ethanol 2 mg/mL (6.46 mM) Water Insoluble

Appearance

pink powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I5440 MSDS PDF

Info Sheet

I5440 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Janes MR, Vu C, Mallya S, et al. Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia. Leukemia. 2013 Mar;27(3):586-94. PMID: 23090679.

Hsieh AC, Liu Y, Edlind MP, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 Feb 22;485(7396):55-61. PMID: 22367541.

Maiso P, Liu Y, Morgan B, et al. Defining the role of TORC1/2 in multiple myeloma. Blood. 2011 Dec 22;118(26):6860-70. PMID: 22045983.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N3378

    S-Nitrosoglutathione

    NO donor.

    ≥95%
  • T3200

    Ticagrelor

    Nucleoside (adenosine) analog; P2Y12 antagonist...

    ≥98%
  • A9617

    Azelnidipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • H9726

    Hygromycin B

    Protein translocation inhibitor.

    ≥95.0%
  • T2835

    6-Thioguanine

    Nucleotide (guanine) analog, prevents guanine s...

    ≥90%
  • G7444

    GSK-1070916

    AurKB/C inhibitor.

    ≥98%
  • D3210

    Diclofenac free acid

    Somewhat selective in inhibiting COX-2 over COX...

    ≥99%
  • D5897

    Doxycycline Hyclate

    Tetracycline; protein translation inhibitor, MM...

    ≥97%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • H1695

    S-Hexylglutathione

    Glutathione-S-transferase inhibitor.

    ≥98%
  • Z161023

    β-Zearalanol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • T1777

    S,S-(+)-Tetrandrine

    Benzylisoquinoline alkaloid originally found in...

    ≥98%
  • S1607

    Secretin, rat

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • C5864

    Coptisine Chloride, synthetic

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • P0244

    Palbociclib Hydrochloride

    CDK4/6 inhibitor.

    ≥99%
  • D183744

    Destruxin A

    Cyclic depsipeptide is a secondary metabolite i...

    ≥98%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • T1656

    Tenoxicam Impurity B

    Tenoxicam impurity

    ≥98%
  • M188776

    9-(Methylsulfonyl)nonanyl nitrile

    Synthetic nitrile compound

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only