Description
Intepirdine is a selective 5-HT6 receptor antagonist. Lab studies have shown it has cognition enhancing effects and may be useful in the battle against Alzheimer’s and other neurodegenerative diseases.
Intepirdine
Product ID I544766
Cas No. 607742-69-8
Purity ≥98%
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Product Info
| Cas No. | 607742-69-8 |
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| Purity | ≥98% |
| Formula | C19H19N3O2S |
| Formula Wt. | 353.44 |
| Chemical Name | 3-(Phenylsulfonyl)-8-(1-piperazinyl)quinoline |
| IUPAC Name | 3-(benzenesulfonyl)-8-piperazin-1-ylquinoline |
| Synonym | GSK-742457,SB-742457 |
| Solubility | Insoluble in water. Soluble in DMSO (60 mg/mL), ethanol (2 mg/mL). |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Grychowska K, Sataka G, Kos T, et al. Novel 1H-pyrrolo[3,2-c]quinoline based 5-HT6 receptor antagonists with potential application for the treatment of cognitive disorders associated with Alzheimer’s disease. ACS Chem Neurosci. 2016 Jul 20;7(7):972-983. PMID: 27100049.
Higgs S, Cooper AJ, Barnes NM. The 5-HT2C receptor agonist, locaserin, and the 5-HT6 receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour. Psychopharmacology (Berl). 2016 Feb;233(3):417-424. PMID: 26507195.
de Bruin NM, van Drimmelen M, Kops M, et al. Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats. Behav Brain Res. 2013 May 1;244:15-28. PMID: 23384714.
Callaghan CK, Hok V, Della-Chiesa A, et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63(5):890-897. PMID: 22766392.
Idris N, Neill J, Grayson B, et al. Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5HT(6) and 5-HT(2A) receptor mechanisms. Psychopharmacology (Berl). 2010 Jan;208(1):23-36. PMID: 19851757.