Irsogladine Maleate

Name: Irsogladine Maleate
SKU: I7074
Availability: InStock

Product ID I7074

Cas No. 84504-69-8

Purity ≥98%

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Description

Irsogladine exhibits anti-inflammatory, anti-fibrotic, and mucoprotective activities. Irsogladine decreases non-steroidal anti-inflammatory drug (NSAID)-induced intestinal mucosal injury, ulcers, and esophagitis; it inhibits COX-1 and COX-2. In animal models of colitis, irsogladine prevents DDS-induced increases in TGF-β1, collagen type 1, MMP2, TIMP-1, and α-SMA, preventing fibrosis. Additionally, irsogladine non-selectively inhibits phosphodiesterases, increasing cAMP and NO, facilitating gap junction communication and altering gastric mucosal blood flow.

Product Info

Cas No.	84504-69-8
Purity	≥98%
Formula	C₉H₇Cl₂N₅ • C₄H₄O₄
Formula Wt.	372.17
Chemical Name	6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
IUPAC Name	(Z)-but-2-enedioic acid;6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
Synonym	MN-1695, Gaslon
Melting Point	289-294°C
Solubility	Soluble in DMSO.
Appearance	White Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	I7074 MSDS PDF
Info Sheet	I7074 Info Sheet PDF

References

Kuramoto T, Umegaki E, Nouda S, et al. Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study. BMC Gastroenterol. 2013 May 14;13:85. PMID: 23672202.

Akagi M, Amagase K, Murakami T, et al. Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract. Curr Pharm Des. 2013;19(1):106-14. PMID: 22950502.

Yamaguchi H, Suzuki K, Nagata M, et al. Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Med Mol Morphol. 2012 Jun;45(3):140-51. PMID: 23001296.

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Irsogladine Maleate

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Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

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