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Ivermectin is an avermectin-family antibiotic that exhibits anti-parasitic/anti-helminthic activity. Ivermectin activates glutamate-gated Cl- channels, interfering with neurotransmission and muscle function in arthropods and nematodes. At high doses, ivermectin also activates GABA-A receptors and glycine receptors.
| Cas No. | 70288-86-7 |
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| Purity | ≥95% |
| Formula | C48H74O14 |
| Formula Wt. | 875.09 |
| Chemical Name | 22,23-Dihydroabamectin |
| IUPAC Name | (1R,4S,6R,10E,14E,16E,21R)-6'-butan-2-yl-21,24-dihydroxy-12-[(2R,4S,6S)-5-[(2S,4S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one |
| Synonym | 22,23-Dihydroavermectin B1, MK-933, Heartgard 30, Mectizan, Stromectol, Zimecterin |
| Melting Point | 155°C |
| Solubility | Soluble in methyl ethyl ketone, propylene glycol, and polyethylene glycol. Insoluble in water. |
| Appearance | White crystalline powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Chaccour CJ, Kobylinski KC, Bassat Q, et al. Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination. Malar J. 2013 May 7;12:153. PMID: 23647969.
Lynagh T, Lynch JW. Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin. Front Mol Neurosci. 2012 May 7;5:60. PMID: 22586367.
Yates DM, Wolstenholme AJ. An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis. Int J Parasitol. 2004 Aug;34(9):1075-81. PMID: 15313134.