• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Kahweol

Kahweol

Product ID K0030
Cas No. 6894-43-5
Purity ≥97%
Product Unit SizeCostQuantityStock
5 mg $127.40 In stock
10 mg $200.10 In stock
25 mg $392.50 Please Inquire
100 mg $874.90 In stock
500 mg $3,015.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Kahweol is a diterpene found in coffee beans that exhibits neuromodulatory, anti-osteoporotic, anti-resorptive, anti-inflammatory, antioxidative, anti-angiogenic, anticancer, and chemopreventive activities. Like other coffee compounds, kahweol may also display hyperlipidemic properties. In vitro, kahweol inhibits RANKL-induced osteoclast generation and bone resorbing activity. In other cellular and animal models, kahweol inhibits cell proliferation, migration, invasion, and tube formation, and suppresses expression of MCP-1 and COX-2. Additionally, kahweol activates Nrf2. In oral squamous cell carcinoma cells, this compound induces G1 phase cell cycle arrest and apoptosis and downregulates expression of Sp1. In vitro, kahweol inhibits aflatoxin B1-induced DNA adduct formation and increases levels of glutathione-S-transferase. This compound also inhibits H2O2-induced DNA damage and oxidative stress and decreases superoxide anion formation in vitro.

Product Info

Cas No.

6894-43-5

Purity

≥97%

Formula

C20H26O3

Formula Wt.

314.42

IUPAC Name

(1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6,10-trien-17-ol

Melting Point

143-144°C

Solubility

Soluble in ethanol (5 mg/mL), DMF (5 mg/mL), DMSO (3 mg/mL).

Appearance

Slightly yellowish solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

K0030 MSDS PDF

Info Sheet

K0030 Info Sheet PDF

References

Chae JI, Jeon YJ, Shim JH. Anti-Proliferative Properties of Kahweol in Oral Squamous Cancer Through the Regulation Specificity Protein 1. Phytother Res. 2014 Sep 8. [Epub ahead of print]. PMID: 25196544.

Wu KC, McDonald PR, Liu J, et al. Screening of natural compounds as activators of the keap1-nrf2 pathway. Planta Med. 2014 Jan;80(1):97-104. PMID: 24310212.

Fumimoto R, Sakai E, Yamaguchi Y, et al. The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation. J Pharmacol Sci. 2012;118(4):479-86. PMID: 22447306.

Cárdenas C, Quesada AR, Medina MA. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. PLoS One. 2011;6(8):e23407. Erratum in: PLoS One. 2011;6(11). PMID: 21858104.

Lee KJ, Jeong HG. Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicol Lett. 2007 Sep 10;173(2):80-7. PMID: 17689207.

Cavin C, Mace K, Offord EA, et al. Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells. Food Chem Toxicol. 2001 Jun;39(6):549-56. PMID: 11346484.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M8007

    Mubritinib, Free Base

    EGFR2 inhibitor.

    ≥99%
  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • S1845

    L-(+)-Selenomethionine

    Naturally occurring amino acid found in grains,...

    ≥98%
  • S1968

    Seratrodast

    TxA2 antagonist.

    ≥99%
  • C5600

    CO-1686

    EGFR (WT, T790M) inhibitor.

    ≥98%
  • L0077

    Latrunculin B

    Thiazolidinone macrolide found in the Red Sea s...

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • O4672

    Olsalazine Sodium

    5-Aminosalicylate prodrug, NSAID; COX-1/2 inhib...

    ≥98%
  • B242042

    BGB-283

    Dual RAF/EGFR inhibitor.

    ≥98%
  • C2844

    Chloramphenicol

    Protein translation inhibitor, peptidyl transfe...

    ≥98%
  • T176503

    Temsirolimus

    Analog of rapamycin.

    ≥98%
  • D1859

    2-Deoxy-D-glucose

    Glucose metabolism inhibitor, N-linked glycosyl...

    ≥99%
  • G7242

    GSK-690693

    Akt inhibitor.

    ≥99%
  • S8244

    Sulbactam

    β-lactamase inhibitor.

    ≥98%
  • P8382

    Puupehenone

    Sesquiterpene found in marine sponges.

    ≥94%
  • S7601

    Statil

    Aldose reductase inhibitor.

    ≥98%
  • P9869

    Pyridoxine Hydrochloride

    Vitamin B6 derivative, antioxidant.

    ≥98%
  • G1721

    Gefitinib

    EGFR inhibitor.

    ≥98%
  • B8363

    Bupropion Hydrochloride

    α3β2, α3β4, α4β2 nAChR antagonist, indire...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only