LKT Labs

Biochemicals for Life Science Research

KN-93

Product ID K5200
Cas No. 1188890-41-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $75.10 Please Inquire
5 mg $218.90 Please Inquire
25 mg $600.20 Please Inquire
Bulk Quote
Browse Wishlist

Quicklinks

Description

KN-93 is an inhibitor of calmodulin-dependent kinase II (CaMKII); it may also inhibit L-type Ca2+ channels. KN-93 exhibits anticancer, anti-arrhythmic, cardiomodulatory, antinociceptive, and immunomodulatory activities. In vitro, KN-93 decreases VEGF expression. When combined with VEGF inhibitors, this compound decreases tumor growth in animal models of cancer. In other animal models, KN-93 prevents the development of arrhythmia and increases levels of Treg cells. KN-93 also increases withdrawal latency in animal models of thermal and mechanical pain.

Product Info

Cas No.

1188890-41-6
Purity

≥98%
Formula

C26H29ClN2O4S・H3O4P
Formula Wt.

599.03
Chemical Name

N-[2-({[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1:1)
IUPAC Name

N-[2-({[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino}methyl)phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1:1)
Synonym

2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
Solubility

Soluble in water
Appearance

White to off-white solid.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

K5200 MSDS PDF
Info Sheet

K5200 Info Sheet PDF

References

Takeuchi M, Yamamoto T. Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. Exp Cell Res. 2015 Jul 1;335(1):62-7. PMID: 26024774.

Tzimas C, Terrovitis J, Lehnart SE, et al. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm. 2015 Jul;12(7):1599-610. PMID: 25814413.

Daft PG, Yang Y, Napierala D, et al. The growth and aggressive behavior of human osteosarcoma is regulated by a CaMKII-controlled autocrine VEGF signaling mechanism. PLoS One. 2015 Apr 10;10(4):e0121568. PMID: 25860662.

Bian H, Yu LC. Intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase II inhibitor KN93 induced antinociception in rats with mononeuropathy. Neurosci Lett. 2014 Nov 7;583:6-10. PMID: 25218714.

Koga T, Mizui M, Yoshida N, et al. KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice. Autoimmunity. 2014 Nov;47(7):445-50. PMID: 24829059.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.